Krzyzanowski Michelle C, Woldemariam Sarah, Wood Jordan F, Chaubey Aditi H, Brueggemann Chantal, Bowitch Alexander, Bethke Mary, L'Etoile Noelle D, Ferkey Denise M
Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, New York, United States of America.
Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California, United States of America.
PLoS Genet. 2016 Jul 26;12(7):e1006153. doi: 10.1371/journal.pgen.1006153. eCollection 2016 Jul.
All animals rely on their ability to sense and respond to their environment to survive. However, the suitability of a behavioral response is context-dependent, and must reflect both an animal's life history and its present internal state. Based on the integration of these variables, an animal's needs can be prioritized to optimize survival strategies. Nociceptive sensory systems detect harmful stimuli and allow for the initiation of protective behavioral responses. The polymodal ASH sensory neurons are the primary nociceptors in C. elegans. We show here that the guanylyl cyclase ODR-1 functions non-cell-autonomously to downregulate ASH-mediated aversive behaviors and that ectopic cGMP generation in ASH is sufficient to dampen ASH sensitivity. We define a gap junction neural network that regulates nociception and propose that decentralized regulation of ASH signaling can allow for rapid correlation between an animal's internal state and its behavioral output, lending modulatory flexibility to this hard-wired nociceptive neural circuit.
所有动物都依靠其感知和响应环境的能力来生存。然而，行为反应的适宜性取决于具体情境，并且必须反映动物的生活史及其当前的内部状态。基于这些变量的整合，可以对动物的需求进行优先级排序，以优化生存策略。伤害性感觉系统检测有害刺激，并引发保护性的行为反应。多模式ASH感觉神经元是秀丽隐杆线虫中的主要伤害感受器。我们在此表明，鸟苷酸环化酶ODR-1以非细胞自主的方式发挥作用，下调ASH介导的厌恶行为，并且ASH中异位的cGMP生成足以降低ASH的敏感性。我们定义了一个调节伤害感受的间隙连接神经网络，并提出ASH信号的分散调节可以使动物的内部状态与其行为输出之间实现快速关联，为这个硬连线的伤害性神经回路赋予调节灵活性。
