Mende Katrin, Beckius Miriam L, Zera Wendy C, Yu Xin, Li Ping, Tribble David R, Murray Clinton K
Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; San Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
San Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA.
Diagn Microbiol Infect Dis. 2016 Oct;86(2):211-20. doi: 10.1016/j.diagmicrobio.2016.07.014. Epub 2016 Jul 15.
There is concern that susceptibility of Staphylococcus aureus to tetracyclines may decrease due to use of antimalarial prophylaxis (doxycycline). We examined characteristics related to tetracycline resistance, including doxycycline exposure, in S. aureus isolates collected via admission surveillance swabs and inpatient clinical cultures from United States military personnel injured during deployment (June 2009-January 2012). Tetracycline class resistance was determined using antimicrobial susceptibility testing. The first S. aureus isolate from 168 patients were analyzed, of which 38 (23%) isolates were resistant to tetracyclines (class). Tetracycline-resistant isolates had a higher proportion of resistance to clindamycin (P=0.019) compared to susceptible isolates. There was no significant difference in tetracycline resistance between isolates collected from patients with and without antimalarial prophylaxis; however, significantly more isolates had tet(M) resistance genes in the doxycycline exposure group (P=0.031). Despite 55% of the patients receiving doxycycline as antimalarial prophylaxis, there was no association with resistance to tetracyclines.
有人担心，由于使用抗疟预防药物（强力霉素），金黄色葡萄球菌对四环素的敏感性可能会降低。我们通过对2009年6月至2012年1月部署期间受伤的美国军事人员入院监测拭子和住院临床培养物中收集的金黄色葡萄球菌分离株，检查了与四环素耐药性相关的特征，包括强力霉素暴露情况。使用抗菌药物敏感性试验确定四环素类耐药性。对168例患者的首个金黄色葡萄球菌分离株进行了分析，其中38株（23%）分离株对四环素（类）耐药。与敏感分离株相比，四环素耐药分离株对克林霉素的耐药比例更高（P=0.019）。接受和未接受抗疟预防的患者所分离的菌株在四环素耐药性方面没有显著差异；然而，在强力霉素暴露组中，携带tet(M)耐药基因的分离株明显更多（P=0.031）。尽管55%的患者接受强力霉素作为抗疟预防药物，但这与对四环素的耐药性并无关联。
