Nishimura N
Department of Obstetrics and Gynecology, Niigata University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Apr;41(4):427-33.
There are several controversies related to labor initiation in term. I therefore tried to analyse the relationship between the onset of labor and the dynamics of catecholamine-concentrations in amniotic fluid using the LC-EC method. Results are as follows. 1. Dopamine levels in amniotic fluid increased with gestational age. 2. Norepinephrine and Dopamine levels were higher in women with uterine contraction than in those without uterine contraction. 3. PGF2 alpha production in amnion increased significantly when it was incubated thirty minutes with CAs compared to that incubated only with Hanks' BSS. The PGE production rate in amnion was five or six times as great as that in PGF2 alpha. In conclusion, it is supposed that CAs in amniotic fluid may play a role in the initiation of uterine contraction.
足月分娩发动存在若干争议。因此，我尝试使用液相色谱 - 电化学检测法分析分娩发动与羊水儿茶酚胺浓度动态变化之间的关系。结果如下：1. 羊水中多巴胺水平随孕周增加而升高。2. 有子宫收缩的女性其去甲肾上腺素和多巴胺水平高于无子宫收缩的女性。3. 与仅用汉克斯平衡盐溶液（Hanks' BSS）孵育相比，羊膜与儿茶酚胺（CAs）孵育30分钟后，羊膜中前列腺素F2α（PGF2α）的产生显著增加。羊膜中前列腺素E（PGE）的产生速率是前列腺素F2α的五到六倍。总之，推测羊水中的儿茶酚胺可能在子宫收缩发动中起作用。
