López Bernal A, Bryant-Greenwood G D, Hansell D J, Hicks B R, Greenwood F C, Turnbull A C
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford.
Br J Obstet Gynaecol. 1987 Nov;94(11):1045-51. doi: 10.1111/j.1471-0528.1987.tb02288.x.
The effect of relaxin on prostaglandin E (PGE) production by human amnion in vitro was investigated. When amniotic discs were incubated in the presence of increasing concentrations of relaxin, two distinct effects were observed. Discs prepared from women delivered by caesarean section before the onset of labour showed a significant decrease in PGE output at relaxin concentrations of 0.5-2 micrograms/ml; the effect was abolished at higher relaxin concentrations. Discs obtained from women delivered after labour of spontaneous onset responded to the addition of relaxin (4-8 micrograms/ml) with a significant increase in PGE output, although this increase was only evident in patients in whom labour had started with intact membranes. These results suggest that relaxin, which is present in decidua and chorion laeve at term, may have a paracrine effect on the amnion, inhibiting PGE production during continuing pregnancy but favouring its production during spontaneous labour.
研究了松弛素对人羊膜体外产生前列腺素E（PGE）的影响。当羊膜盘在浓度不断增加的松弛素存在下孵育时，观察到两种不同的效应。在分娩开始前接受剖宫产的女性所制备的羊膜盘，在松弛素浓度为0.5 - 2微克/毫升时，PGE产量显著下降；在更高的松弛素浓度下，这种效应消失。从自然发动分娩后的女性获得的羊膜盘，加入松弛素（4 - 8微克/毫升）后PGE产量显著增加，尽管这种增加仅在胎膜完整开始分娩的患者中明显。这些结果表明，足月时存在于蜕膜和胎膜中的松弛素可能对羊膜有旁分泌作用，在持续妊娠期间抑制PGE的产生，但在自然分娩期间促进其产生。
