自闭症谱系障碍的治疗进展：羊膜间充质干细胞移植
Advances in the treatment of autism spectrum disorder: Wharton jelly mesenchymal stem cell transplantation.
作者信息
Kabatas Serdar, Civelek Erdinç, Savrunlu Eyüp Can, Karaaslan Umut, Yıldız Özlem, Karaöz Erdal
机构信息
Department of Neurosurgery, University of Health Sciences Turkey, Gaziosmanpaşa Training and Research Hospital, Istanbul 34255, Türkiye.
Department of Pediatric Allergy-Immunology, Institute of Health Sciences Marmara University, Istanbul 34865, Türkiye.
出版信息
World J Methodol. 2025 Mar 20;15(1):95857. doi: 10.5662/wjm.v15.i1.95857.
BACKGROUND
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multifaceted origins. In recent studies, neuroinflammation and immune dysregulation have come to the forefront in its pathogenesis. There are studies suggesting that stem cell therapy may be effective in the treatment of ASD.
AIM
To evolve the landscape of ASD treatment, focusing on the potential benefits and safety of stem cell transplantation.
METHODS
A detailed case report is presented, displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) transplantation combined with neurorehabilitation.
RESULTS
The study demonstrates a significant improvement in the child's functional outcomes (Childhood Autism Rating Scale, Denver 2 Developmental Screening Test), especially in language and gross motor skills. No serious side effects were encountered during the 2-year follow-up.
CONCLUSION
The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.
背景
自闭症谱系障碍（ASD）是一种起源多方面的复杂神经发育障碍。在最近的研究中，神经炎症和免疫失调在其发病机制中占据了突出地位。有研究表明干细胞疗法可能对ASD的治疗有效。
目的
以干细胞移植的潜在益处和安全性为重点，拓展ASD治疗的格局。
方法
呈现一份详细的病例报告，展示了一名接受鞘内和静脉注射来自脐带华通氏胶的间充质干细胞（WJ-MSCs）移植并结合神经康复治疗的儿童所观察到的积极结果。
结果
该研究表明该儿童的功能结局（儿童自闭症评定量表、丹佛发育筛查测验第二版）有显著改善，尤其是在语言和粗大运动技能方面。在2年的随访期间未出现严重副作用。
结论
这些发现支持了WJ-MSC移植治疗ASD的安全性和有效性。
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