Kasper Isaac R, Apostolidis Sokratis A, Sharabi Amir, Tsokos George C
Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Trends Mol Med. 2016 Sep;22(9):784-797. doi: 10.1016/j.molmed.2016.07.003. Epub 2016 Jul 25.
Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, including various transcription factors, phosphatases, and kinases, impact the ability of Tregs to function as negative regulators of the immune response, and are presumably amenable to therapeutic manipulation. Here, we discuss recently identified molecular networks and the therapeutic potential for treating autoimmune diseases.
调节性T细胞(Tregs)能够减轻免疫介导的炎症,并避免不受控制的炎症所带来的破坏作用。包括各种转录因子、磷酸酶和激酶在内的不同分子和信号通路,会影响Tregs作为免疫反应负调节因子的功能,并且可能适用于治疗性调控。在此,我们讨论最近发现的分子网络以及治疗自身免疫性疾病的治疗潜力。