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来自链格孢菌的茎点霉毒素III

Stemphyltoxin III from Alternaria alternata.

作者信息

Stack M E, Mazzola E P

机构信息

Division of Contaminants Chemistry, Food and Drug Administration, Washington, D.C. 20204.

出版信息

J Nat Prod. 1989 Mar-Apr;52(2):426-7. doi: 10.1021/np50062a042.

DOI:10.1021/np50062a042
PMID:2746264
Abstract

Stemphyltoxin III, (6aR*, 6bS*, 7R*, 8R*)-3,6a, 10-trihydroxy-4,9-dioxo-4,6a,6b,7,8,9-hexahydro-7,8-epoxyperylene, a known metabolite of Stemphylium botryosum var. lactucum, has been identified as a mutagenic metabolite of Alternaria alternata by spectroscopic studies. The 13C-nmr spectral data, which were not reported previously, are presented.

摘要

匐柄霉素III,即(6aR*, 6bS*, 7R*, 8R*)-3,6a, 10-三羟基-4,9-二氧代-4,6a,6b,7,8,9-六氢-7,8-环氧苝,是匐柄霉莴苣变种的一种已知代谢产物,通过光谱研究已被鉴定为链格孢的一种诱变代谢产物。本文给出了之前未报道过的13C-核磁共振光谱数据。

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Stemphyltoxin III from Alternaria alternata.来自链格孢菌的茎点霉毒素III
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引用本文的文献

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J Fungi (Basel). 2022 Feb 9;8(2):168. doi: 10.3390/jof8020168.
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Chemotaxonomy of Mycotoxigenic Small-Spored Fungi - Do Multitoxin Mixtures Act as an Indicator for Species Differentiation?产毒小孢子真菌的化学分类学——多毒素混合物是否可作为物种分化的指标?
Front Microbiol. 2018 Jul 3;9:1368. doi: 10.3389/fmicb.2018.01368. eCollection 2018.
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Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase.
链格孢属而非镰刀菌属霉菌毒素对人拓扑异构酶II和细菌促旋酶的双重作用。
Arch Toxicol. 2017 Apr;91(4):2007-2016. doi: 10.1007/s00204-016-1855-z. Epub 2016 Sep 28.
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Permeation and metabolism of Alternaria mycotoxins with perylene quinone structure in cultured Caco-2 cells.具有二萘嵌苯醌结构的交链孢霉毒素在体外培养的 Caco-2 细胞中的渗透和代谢。
Mycotoxin Res. 2014 Feb;30(1):17-23. doi: 10.1007/s12550-013-0180-0. Epub 2013 Oct 31.
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Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium.评估链格孢酚及链格孢酚甲醚对鼠伤寒沙门氏菌的致突变活性。
Appl Environ Microbiol. 1994 Oct;60(10):3901-2. doi: 10.1128/aem.60.10.3901-3902.1994.
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