链格孢菌代谢产物变应毒素I、II和III的致突变性。
Mutagenicity of the Alternaria metabolites altertoxins I, II, and III.
作者信息
Stack M E, Prival M J
出版信息
Appl Environ Microbiol. 1986 Oct;52(4):718-22. doi: 10.1128/aem.52.4.718-722.1986.
Abstract
The Ames Salmonella typhimurium assay was used to demonstrate that an extract of the mold Alternaria alternata was mutagenic. The mutagenic extract was fractionated, and the Ames test was used to determine which fractions were mutagenic. Subsequently, altertoxins I and II and a new compound referred to as altertoxin III were isolated by liquid chromatography and shown to be hydroxyperylenequinone compounds by mass spectrometry and infrared, ultraviolet, and proton magnetic resonance spectroscopy. Altertoxins I, II, and III were mutagenic to S. typhimurium TA98, TA100, and TA1537 with and without metabolic activation.
摘要
采用鼠伤寒沙门氏菌艾姆斯试验来证明链格孢霉菌提取物具有致突变性。对具有致突变性的提取物进行分级分离，并用艾姆斯试验来确定哪些级分具有致突变性。随后，通过液相色谱法分离出变应毒素I和II以及一种称为变应毒素III的新化合物，并通过质谱、红外、紫外和质子磁共振光谱证明它们是羟基苝醌化合物。变应毒素I、II和III无论有无代谢活化作用，对鼠伤寒沙门氏菌TA98、TA100和TA1537均具有致突变性。
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