评估链格孢酚及链格孢酚甲醚对鼠伤寒沙门氏菌的致突变活性。
Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium.
作者信息
Davis V M, Stack M E
机构信息
Division of Molecular Biological Research and Evaluation, U.S. Food and Drug Administration, Washington, D.C. 20204.
出版信息
Appl Environ Microbiol. 1994 Oct;60(10):3901-2. doi: 10.1128/aem.60.10.3901-3902.1994.
Abstract
Alternariol and alternariol methyl ether were tested in the Ames Salmonella typhimurium assay, and both were shown, with and without metabolic activation, to be nonmutagenic to strains TA98 and TA100. The finding of other investigators that alternariol methyl ether is weakly mutagenic to TA98 without metabolic activation could have resulted from the presence of a small amount of one of the highly mutagenic altertoxins in the alternariol methyl ether originally tested.
摘要
在鼠伤寒沙门氏菌艾姆斯试验中对链格孢酚和链格孢酚单甲醚进行了检测，结果表明，无论有无代谢活化，二者对TA98和TA100菌株均无致突变性。其他研究人员发现链格孢酚单甲醚在无代谢活化的情况下对TA98有微弱的致突变性，这可能是由于最初检测的链格孢酚单甲醚中存在少量高致突变性的交链孢毒素之一。
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本文引用的文献
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