细胞生物学：通向蛋白质降解的TORC1信号通路。 - Suppr

Cell biology: The TORC1 pathway to protein destruction.

作者信息

Chantranupong Lynne, Sabatini David M

出版信息

Nature. 2016 Aug 11;536(7615):155-6. doi: 10.1038/nature18919. Epub 2016 Jul 27.

DOI:10.1038/nature18919

PMID:27462809

Abstract

摘要

相似文献

Cell biology: The TORC1 pathway to protein destruction.

Nature. 2016 Aug 11;536(7615):155-6. doi: 10.1038/nature18919. Epub 2016 Jul 27.

Transient sequestration of TORC1 into stress granules during heat stress.

Mol Cell. 2012 Jul 27;47(2):242-52. doi: 10.1016/j.molcel.2012.05.019. Epub 2012 Jun 21.

TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae.

J Cell Sci. 2009 Jun 15;122(Pt 12):2089-99. doi: 10.1242/jcs.047191.

Nitrogen starvation and TorC1 inhibition differentially affect nuclear localization of the Gln3 and Gat1 transcription factors through the rare glutamine tRNACUG in Saccharomyces cerevisiae.

Genetics. 2015 Feb;199(2):455-74. doi: 10.1534/genetics.114.173831. Epub 2014 Dec 19.

Leucyl-tRNA synthetase controls TORC1 via the EGO complex.

Mol Cell. 2012 Apr 13;46(1):105-10. doi: 10.1016/j.molcel.2012.02.009. Epub 2012 Mar 15.

TOR signaling is a determinant of cell survival in response to DNA damage.

Mol Cell Biol. 2007 Oct;27(20):7007-17. doi: 10.1128/MCB.00290-07. Epub 2007 Aug 13.

TORC1 inhibition induces lipid droplet replenishment in yeast.

Mol Cell Biol. 2015 Feb;35(4):737-46. doi: 10.1128/MCB.01314-14. Epub 2014 Dec 15.

A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations.

Sci Rep. 2016 Feb 23;6:21874. doi: 10.1038/srep21874.

SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.

J Cell Sci. 2015 Jun 15;128(12):2219-28. doi: 10.1242/jcs.168922. Epub 2015 May 1.

The TORC1 signaling pathway regulates respiration-induced mitophagy in yeast.

Biochem Biophys Res Commun. 2018 Jul 7;502(1):76-83. doi: 10.1016/j.bbrc.2018.05.123. Epub 2018 May 24.

引用本文的文献

Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3-their sensing mediator-is tumor suppressive.

Cell Death Differ. 2024 Oct;31(10):1242-1254. doi: 10.1038/s41418-024-01370-x. Epub 2024 Sep 12.

Interpreting protein abundance in Saccharomyces cerevisiae through relational learning.

Bioinformatics. 2024 Feb 1;40(2). doi: 10.1093/bioinformatics/btae050.

The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1.

Anim Nutr. 2022 Aug 8;11:121-131. doi: 10.1016/j.aninu.2022.07.010. eCollection 2022 Dec.

Severe Hyperosmotic Stress Issues an ER Stress-Mediated "Death Sentence" in H9c2 Cells, with p38-MAPK and Autophagy "Coming to the Rescue".

Biomedicines. 2022 Jun 15;10(6):1421. doi: 10.3390/biomedicines10061421.

Dot6/Tod6 degradation fine-tunes the repression of ribosome biogenesis under nutrient-limited conditions.

iScience. 2022 Feb 26;25(3):103986. doi: 10.1016/j.isci.2022.103986. eCollection 2022 Mar 18.

Moonlighting Proteins: The Case of the Hexokinases.

Front Mol Biosci. 2021 Jun 9;8:701975. doi: 10.3389/fmolb.2021.701975. eCollection 2021.

Interactions between Growth of Muscle and Stature: Mechanisms Involved and Their Nutritional Sensitivity to Dietary Protein: The Protein-Stat Revisited.

Nutrients. 2021 Feb 25;13(3):729. doi: 10.3390/nu13030729.

Expanding the role of proteasome homeostasis in Parkinson's disease: beyond protein breakdown.

Cell Death Dis. 2021 Feb 4;12(2):154. doi: 10.1038/s41419-021-03441-0.

Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control.

Molecules. 2021 Jan 14;26(2):407. doi: 10.3390/molecules26020407.

Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases.

Transl Neurodegener. 2020 Oct 30;9(1):40. doi: 10.1186/s40035-020-00219-w.

本文引用的文献

An evolutionarily conserved pathway controls proteasome homeostasis.

Nature. 2016 Aug 11;536(7615):184-9. doi: 10.1038/nature18943. Epub 2016 Jul 27.

Control of proteasomal proteolysis by mTOR.

Nature. 2016 Jan 21;529(7586):E1-2. doi: 10.1038/nature16472.

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15790-7. doi: 10.1073/pnas.1521919112. Epub 2015 Dec 15.

Coordinated regulation of protein synthesis and degradation by mTORC1.

Nature. 2014 Sep 18;513(7518):440-3. doi: 10.1038/nature13492. Epub 2014 Jul 13.

An inducible chaperone adapts proteasome assembly to stress.

Mol Cell. 2014 Aug 21;55(4):566-77. doi: 10.1016/j.molcel.2014.06.017. Epub 2014 Jul 17.

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

Nature. 2013 Jan 31;493(7434):679-83. doi: 10.1038/nature11745. Epub 2012 Dec 23.

Failure of amino acid homeostasis causes cell death following proteasome inhibition.

Mol Cell. 2012 Oct 26;48(2):242-53. doi: 10.1016/j.molcel.2012.08.003. Epub 2012 Sep 6.

mTOR signaling in growth control and disease.

Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.

Recognition and processing of ubiquitin-protein conjugates by the proteasome.

Annu Rev Biochem. 2009;78:477-513. doi: 10.1146/annurev.biochem.78.081507.101607.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Cell biology: The TORC1 pathway to protein destruction.

作者信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献