无过渡金属参与的芳基炔与酮和炔酸酯的偶联环化反应：功能化萘的构建。
Transition-Metal-Free Coupling Annulation of Arynes with Ketones and Alkynoates: Assembly of Functionalized Naphthalenes.
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Hubei, Wuhan 430079, P. R. China.
College of Chemistry and Environmental Engineering, Yangtze University , Jingzhou 434023, P. R. China.
出版信息
Org Lett. 2016 Aug 5;18(15):3762-5. doi: 10.1021/acs.orglett.6b01782. Epub 2016 Jul 27.
A transition-metal-free coupling annulation reaction of arynes, ketones, and alkynoates has been demonstrated. Using this formal [2 + 2 + 2] cycloaddition reaction, a wide variety of naphthalene derivatives were conveniently constructed in one pot with high efficiency. In addition, this novel and valid annulation has been successfully applied to the synthesis of 1-phenanthrenol derivatives.
芳炔、酮和炔酸酯的无过渡金属偶联环加成反应已经得到证明。通过这种形式的[2+2+2]环加成反应，一锅法高效方便地构建了多种萘衍生物。此外，这种新颖有效的环化反应已成功应用于 1-菲醇衍生物的合成。
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