Sequential σ-Bond Insertion/Benzannulation Involving Arynes: Selective Synthesis of Polysubstituted Naphthalenes.
作者信息
Shu Wen-Ming, Liu Shan, He Jian-Xin, Wang Shuai, Wu An-Xin
机构信息
College of Chemistry and Environmental Engineering , Yangtze University , Jingzhou 434023 , PR China.
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry , Central China Normal University , Wuhan 430079 , PR China.
出版信息
J Org Chem. 2018 Aug 17;83(16):9156-9165. doi: 10.1021/acs.joc.8b01207. Epub 2018 Jun 19.
An interesting σ-bond insertion/benzannulation reaction for the synthesis of polysubstituted naphthalene derivatives has been developed from readily accessible ketones, arynes, and alkynoates. This practical and transition-metal-free method provides a novel route to diverse naphthalenes through a substrate-controlled rearrangement reaction with the cleavage of C-C bonds.
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