Ozer Kutan, Horsanali Mustafa Ozan, Gorgel Sacit Nuri, Horsanali Burcu Ozalp, Ozbek Emin
Department of Urology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.
Urol Int. 2017;98(4):466-471. doi: 10.1159/000448289. Epub 2016 Jul 28.
There is a large body of evidence of clinical studies regarding the relation between metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS) in men. A possible link between inflammation and these 2 clinical entities has also been proposed. Here, we aimed at evaluating the role of neutrophil-lymphocyte ratio (NLR), an indicator of inflammation and MetS, in the pathogenesis of LUTS and other BPH-related parameters.
We evaluated 244 patients with benign prostate hyperplasia admitted to our outpatient clinic between January 2014 and June 2015. NLR was calculated from the peripheral blood sample for all patients. Patients' anthropometric characteristics, serum lipid levels, waist circumferences, total prostate-specific antigen (PSA) and testosterone values, prostate volumes, max values and International Prostate Symptom Score (IPSS) were recorded. All statistical analyses were conducted by SPSS version 17.0 package program, and p value <0.05 was chosen as the criterion for statistical significance.
There was statistical significance between NLR and patients with severe IPSS score (>20) and over age 60 years (p = 0.02). Patients younger than 60 years had statistical significance between NLR and PSA <2.5 ng/dl (p = 0.004). When body mass index was selected, there was statistical significance between prostate volume <35 ml (p = 0.009) and age >60 years (p = 0.028). If 60 years of age was selected as cut-off value, there is statistical significance between age and severe IPSS, and in terms of mild erectile dysfunction, PSA >2.5 ng/dl, and prostate volume >35 ml.
We found positive correlation between NLR and severe symptoms and progression of BPH. In this manner, anti-inflammatory therapy could contribute to the medical treatment of BPH. Higher NLR may be a candidate marker for severity of symptoms in BPH patients.
有大量关于男性代谢综合征（MetS）与良性前列腺增生（BPH）相关下尿路症状（LUTS）之间关系的临床研究证据。也有人提出炎症与这两种临床病症之间可能存在联系。在此，我们旨在评估中性粒细胞与淋巴细胞比值（NLR），一种炎症和MetS的指标，在LUTS发病机制及其他BPH相关参数中的作用。
我们评估了2014年1月至2015年6月期间在我们门诊就诊的244例良性前列腺增生患者。计算所有患者外周血样本中的NLR。记录患者的人体测量特征、血脂水平、腰围、总前列腺特异性抗原（PSA）和睾酮值、前列腺体积、最大值和国际前列腺症状评分（IPSS）。所有统计分析均使用SPSS 17.0软件包程序进行，以p值<0.05作为统计学显著性标准。
NLR与IPSS评分严重（>20）且年龄超过60岁的患者之间存在统计学显著性（p = 0.02）。60岁以下患者中，NLR与PSA<2.5 ng/dl之间存在统计学显著性（p = 0.004）。选择体重指数时，前列腺体积<35 ml（p = 0.009）与年龄>60岁（p = 0.028）之间存在统计学显著性。如果选择60岁作为临界值，年龄与严重IPSS之间以及在轻度勃起功能障碍、PSA>2.5 ng/dl和前列腺体积>35 ml方面存在统计学显著性。
我们发现NLR与BPH的严重症状和进展之间存在正相关。通过这种方式，抗炎治疗可能有助于BPH的药物治疗。较高的NLR可能是BPH患者症状严重程度的一个候选标志物。
