Song Yanqi, Gu Yeqing, Guo Honglei, Yang Honghao, Wang Xuena, Wu Hongmei, Wang Aidi, Wang Haijin, Zhang Quan, Zhang Qing, Liu Li, Meng Ge, Liu Baoshan, Niu Kaijun
Department of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.
J Inflamm Res. 2023 Oct 25;16:4857-4866. doi: 10.2147/JIR.S431049. eCollection 2023.
The prevalence of benign prostatic hyperplasia (BPH) in the general Chinese adult male population has risen sharply over the past few decades. Increasing evidence suggests that inflammation plays an important role in the pathogenesis of BPH. To better understand the role of inflammation in the pathogenesis of BPH, we can use the neutrophil-to-lymphocyte ratio (NLR) because it is a simple and effective marker of inflammation and immunity. This study aims to prospectively investigate the association between NLR levels and the prevalence of BPH in a general Chinese adult male population.
This study included a total of 15,783 male participants free from BPH at baseline. NLR was measured according to the complete blood count. BPH was defined as total prostate volume (TPV) ≥30 mL, and TPV was determined by transabdominal ultrasonography. Multivariable Cox proportional hazards models were fitted to calculate hazards ratios (HRs) and corresponding 95% confidence intervals (CIs) for BPH risk with NLR levels.
During a median follow-up of 2.7 years, 5078 BPH cases were documented. After adjusting for age, body mass index, smoking, alcohol, education, occupation, income, physical activity, total energy intake, personal and family history of disease, and inflammation markers, the multivariable-adjusted HRs of BPH were 1.00 (reference), 1.08 (95% CIs 0.99, 1.17), 1.10 (95% CIs1.02, 1.19), and 1.12 (95% CIs1.03, 1.21), respectively, for participants with NLR in the first, second, third, and fourth quartiles ( for trend <0.01).
Higher NLR levels were associated with a higher risk of BPH in Chinese adult male population. Our findings support the notion that NLR levels may be an important target for BPH prevention and intervention.
在过去几十年中，中国成年男性总体人群中良性前列腺增生（BPH）的患病率急剧上升。越来越多的证据表明，炎症在BPH的发病机制中起重要作用。为了更好地理解炎症在BPH发病机制中的作用，我们可以使用中性粒细胞与淋巴细胞比值（NLR），因为它是炎症和免疫的一个简单有效的标志物。本研究旨在前瞻性调查中国成年男性总体人群中NLR水平与BPH患病率之间的关联。
本研究共纳入15783名基线时无BPH的男性参与者。根据全血细胞计数测量NLR。BPH定义为总前列腺体积（TPV）≥30 mL，TPV通过经腹超声确定。采用多变量Cox比例风险模型计算NLR水平与BPH风险的风险比（HRs）及相应的95%置信区间（CIs）。
在中位随访2.7年期间，记录到5078例BPH病例。在调整年龄、体重指数、吸烟、饮酒、教育程度、职业、收入、身体活动、总能量摄入、个人和家族疾病史以及炎症标志物后，NLR处于第一、第二、第三和第四四分位数的参与者发生BPH的多变量调整后HR分别为1.00（参考值）、1.08（95%CI 0.99，1.17）、1.10（95%CI 1.02，1.19）和1.12（95%CI 1.03，1.21）（趋势P<0.01）。
在中国成年男性人群中，较高的NLR水平与较高的BPH风险相关。我们的研究结果支持NLR水平可能是BPH预防和干预的重要靶点这一观点。
