Department of urology, Baotou central hospital, Botou014040, Inner Mongolia, China.
Baotou Center for Diseases Prevention and Control, Botou014020, Inner Mongolia, China.
Urol J. 2020 Mar 14;17(5):505-511. doi: 10.22037/uj.v0i0.5462.
To evaluate the association between inflammation in prostatic tissue/serum sample and BPH-LUTS Patients and methods: The prostatic tissue and serum sample were collected from 183 patients who underwent transurethral plasmakinetic resection of the prostate (TUPKRP). The association between inflammation detected on prostatic tissues/ serum sample and LUTS related parameters, including International Prostate Symptom Score (IPSS) and peak flow rate (Qmax) were analyzed with SPSS version 13.0, and P-value <0.05 was chosen as the criterion for statistical significance.
There was a positive association between prostate tissue inflammation and LUTS. The differences of IPSS, VSS and SSS were seen with the increasing in grade of prostate tissue inflammation (P<.001; .001; =.014, respectively). Qmax and IPSS 12months after surgery were better in no inflammation group (P=.016; .031).Logistic regression analysis revealed a statistically association between the NEUT%?NLR and prostate tissue inflammation (P=.010; .004), but ROC curve showed the NEUT%, NEUT and NLR area under curve (.526; .452; .513, respectively) were calculated as <0.600. Patients with Qmax over 7.12 had more WBC count in peripheral blood (7.56±1.77 VS 6.37±1.86, P=.026). The NLR was significantly higher in the group of IPSS over 20 and AUR presence (P=.018; .017).The NEUT%, LYMPH%, LYMPH and NLR showed a statistically significance in different obstruction classification (P=.047; .046; .028; .014, respectively).
There was correlation between chronic Inflammation and LUTS related to BPH. The patient without inflammation could acquire more sustained and steady relief than those with inflammation in LUTS related to BPH after TUPKRP.
评估前列腺组织/血清样本中的炎症与 BPH-LUTS 患者之间的关联。
收集了 183 名接受经尿道等离子体前列腺切除术（TUPKRP）的患者的前列腺组织和血清样本。使用 SPSS 版本 13.0 分析了前列腺组织/血清样本中检测到的炎症与 LUTS 相关参数（包括国际前列腺症状评分（IPSS）和最大尿流率（Qmax））之间的关联，选择 P 值<0.05 作为统计学意义的标准。
前列腺组织炎症与 LUTS 之间存在正相关。随着前列腺组织炎症程度的增加，IPSS、VSS 和 SSS 的差异具有统计学意义（P<.001；.001；=.014，分别）。无炎症组术后 12 个月的 Qmax 和 IPSS 更好（P=.016；.031）。Logistic 回归分析显示，NEUT%、NLR 与前列腺组织炎症之间存在统计学关联（P=.010；.004），但 ROC 曲线显示 NEUT%、NEUT 和 NLR 的曲线下面积（分别为.526；.452；.513）计算值<0.600。最大尿流率超过 7.12ml/s 的患者外周血白细胞计数较高（7.56±1.77 VS 6.37±1.86，P=.026）。在 IPSS 超过 20 和 AUR 存在的组中，NLR 显著更高（P=.018；.017）。在不同梗阻分类中，NEUT%、LYMPH%、LYMPH 和 NLR 显示出统计学意义（P=.047；.046；.028；.014，分别）。
慢性炎症与 BPH 相关的 LUTS 之间存在相关性。在 TUPKRP 后，与炎症患者相比，无炎症患者在 BPH 相关的 LUTS 中获得更持续和稳定的缓解。
