Institute for Disease Control and Prevention, Academy of Military Medical Sciences , Beijing 100036, P. R. China.
ACS Appl Mater Interfaces. 2016 Aug 10;8(31):19866-71. doi: 10.1021/acsami.6b07631. Epub 2016 Aug 1.
Multidrug-resistant superbugs are currently a severe threat to public health. Here, we report a novel kind of antisuperbug material prepared by irradiation induced graft polymerization of 1-butyl-3-vinyl imidazole chloride onto cotton fabric. The reduction of superbugs on this fabric is higher than 99.9%. Attributed to the strong covalent bonding between the graft chains and the cellulose macromolecules, the antisuperbug performance did not decrease even after 150 equiv of domestic laundering cycles. Covalent bonding also prevented the release of the antibacterial groups during application and guarantees the safety of the material, which was proved by animal skin irritation and acute oral toxicity tests.
多药耐药超级细菌目前对公众健康构成严重威胁。在这里,我们报告了一种通过辐照引发的 1-丁基-3-乙烯基氯化咪唑接枝到棉织物上的聚合反应制备的新型抗超级细菌材料。这种织物对超级细菌的减少率高于 99.9%。由于接枝链与纤维素大分子之间存在强共价键,因此即使经过 150 当量的家庭洗涤循环,抗超级细菌性能也不会下降。共价键还防止了抗菌基团在应用过程中的释放,并保证了材料的安全性,这一点通过动物皮肤刺激和急性口服毒性试验得到了证明。