Mong F S
Department of Anatomical Sciences, University of Texas, Houston 77225.
J Oral Rehabil. 1989 May;16(3):315-21. doi: 10.1111/j.1365-2842.1989.tb01347.x.
Experimental studies were performed in rats to explore the feasibility of using limb muscles to replace masticatory masseter muscles. The results showed that if several small fusiform muscles such as the extensor digitorum longus (EDL), soleus (SOL) and plantaris (PLT) were used for the grafting, the graft regenerated and matured fully in the masseter bed, although the weights were lower than those of contralateral control masseter muscles. If a multipennate muscle such as the gastrocnemius was used for the grafting, the graft also regenerated but later degenerated due to the lack of innervation. This is probably due to the excessive amount of connective tissue in the multipennate muscle. The connective tissue proliferates faster than the regeneration of muscle fibres and, thus, renders the innervation of muscle fibres difficult. Other factors pertinent to the possible clinical application of muscle transplantation in oral region are discussed.
在大鼠身上进行了实验研究，以探索利用肢体肌肉替代咀嚼咬肌的可行性。结果表明，如果使用几块小型梭形肌肉，如趾长伸肌（EDL）、比目鱼肌（SOL）和跖肌（PLT）进行移植，移植物在咬肌床中能够完全再生并成熟，尽管其重量低于对侧对照咬肌。如果使用多羽状肌，如腓肠肌进行移植，移植物也会再生，但随后会因缺乏神经支配而退化。这可能是由于多羽状肌中结缔组织过多。结缔组织的增殖速度比肌纤维的再生速度快，因此使肌纤维的神经支配变得困难。还讨论了与肌肉移植在口腔区域可能的临床应用相关的其他因素。
