Poulianiti Konstantina, Karatzaferi Christina, Flouris Andreas D, Fatouros Ioannis G, Koutedakis Yiannis, Jamurtas Athanasios Z
a Department of Physical Education & Sport Science , University of Thessaly, TEFAA Karies , Trikala , Greece ;
b Institute of Research and Technology Thessaly, Centre for Research and Technology Hellas , Trikala , Greece ;
Toxicol Mech Methods. 2016 Jul;26(6):455-61. doi: 10.1080/15376516.2016.1196281. Epub 2016 Jul 27.
It has been indicated that acute active and passive tobacco cigarette smoking may cause changes on redox status balance that may result in significant pathologies. However, no study has evaluated the effects of active and passive e-cigarette smoking on redox status of consumers.
To examine the acute effects of active and passive e-cigarette and tobacco cigarette smoking on selected redox status markers.
Using a randomized single-blind crossover design, 30 participants (15 smokers and 15 nonsmokers) were exposed to three different experimental conditions. Smokers underwent a control session, an active tobacco cigarette smoking session (smoked 2 cigarettes within 30-min) and an active e-cigarette smoking session (smoked a pre-determined number of puffs within 30-min using a liquid with 11 ng/ml nicotine). Similarly, nonsmokers underwent a control session, a passive tobacco cigarette smoking session (exposure of 1 h to 23 ± 1 ppm of CO in a 60 m(3) environmental chamber) and a passive e-cigarette smoking session (exposure of 1 h to air enriched with pre- determined number of puffs in a 60 m(3) environmental chamber). Total antioxidant capacity (TAC), catalase activity (CAT) and reduced glutathione (GSH) were assessed in participants' blood prior to, immediately after, and 1-h post-exposure.
TAC, CAT and GSH remained similar to baseline levels immediately after and 1-h-post exposure (p > 0.05) in all trials.
Tobacco and e-cigarette smoking exposure do not acutely alter the response of the antioxidant system, neither under active nor passive smoking conditions. Overall, there is not distinction between tobacco and e-cigarette active and passive smoking effects on specific redox status indices.
已有研究表明，主动和被动吸食传统香烟可能会导致氧化还原状态平衡发生变化，进而引发严重病变。然而，尚无研究评估主动和被动吸食电子烟对消费者氧化还原状态的影响。
研究主动和被动吸食电子烟及传统香烟对选定氧化还原状态标志物的急性影响。
采用随机单盲交叉设计，30名参与者（15名吸烟者和15名非吸烟者）被暴露于三种不同的实验条件下。吸烟者经历一个对照阶段、一个主动吸食传统香烟阶段（30分钟内吸2支烟）和一个主动吸食电子烟阶段（使用含11纳克/毫升尼古丁的液体在30分钟内吸预先确定数量的口数）。同样，非吸烟者经历一个对照阶段、一个被动吸食传统香烟阶段（在60立方米的环境舱中暴露于23±1 ppm的一氧化碳中1小时）和一个被动吸食电子烟阶段（在60立方米的环境舱中暴露于含有预先确定数量口数的富氧空气中1小时）。在暴露前、暴露后即刻和暴露后1小时评估参与者血液中的总抗氧化能力（TAC）、过氧化氢酶活性（CAT）和还原型谷胱甘肽（GSH）。
在所有试验中，暴露后即刻和暴露后1小时，TAC、CAT和GSH均与基线水平相似（p>0.05）。
无论是主动还是被动吸烟条件下，吸食烟草和电子烟均不会急性改变抗氧化系统的反应。总体而言，烟草和电子烟的主动和被动吸烟对特定氧化还原状态指标的影响并无差异。
