Fu Qiang, Satterlee Andrew, Wang Yongjun, Wang Yuhua, Wang Dun, Tang Jingling, He Zhonggui, Liu Feng
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Int J Exp Pathol. 2016 Aug;97(4):351-356. doi: 10.1111/iep.12192. Epub 2016 Jul 28.
This study describes variations in tumour growth patterns which occur when changes in the routes of inoculation and mouse strain are used to introduce tumours into established murine model systems that are known to vary in location and aggression. Intraperitoneal, subcutaneous, intravenous and hydrodynamic inoculations of B16F10 cells were compared among CD-1, C57BL/6 and Balb/c mice. Most surprisingly, allogeneic tumour growth in Balb/c mice after intravenous and hydrodynamic inoculation of B16F10 cells was faster than tumour growth in the syngeneic C57BL/6 mice. These and other variations in the tumour growth patterns described here can help provide the researcher with more experimental control when planning to use the optimal tumour model for any particular study.
本研究描述了在已知肿瘤位置和侵袭性存在差异的既定小鼠模型系统中，通过改变接种途径和小鼠品系来引入肿瘤时所出现的肿瘤生长模式变化。在CD-1、C57BL/6和Balb/c小鼠中比较了B16F10细胞的腹腔内、皮下、静脉内和流体动力学接种。最令人惊讶的是，静脉内和流体动力学接种B16F10细胞后，Balb/c小鼠中的同种异体肿瘤生长比同基因C57BL/6小鼠中的肿瘤生长更快。本文所述的这些以及其他肿瘤生长模式的变化，有助于研究人员在计划为任何特定研究使用最佳肿瘤模型时获得更多实验控制。
