Rudd Penny A, Chen Weiqiang, Mahalingam Suresh
Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia.
Methods Mol Biol. 2016;1442:209-17. doi: 10.1007/978-1-4939-3687-8_15.
Human respiratory syncytial virus (hRSV) is a common respiratory virus that is usually no cause for alarm. Symptoms of hRSV usually resemble those of the common cold and can go undiagnosed. However, infants as well as the elderly are at risk for developing severe cases, which can lead to high morbidity and mortality rates especially if there are underlying health issues. Despite many years of effort, no vaccine or specific treatments exist and RSV is still the leading cause of infant hospitalizations worldwide. Here, we describe methods to infect two widely used small animal models: laboratory mice and cotton rats.
人呼吸道合胞病毒（hRSV）是一种常见的呼吸道病毒，通常无需担忧。hRSV的症状通常与普通感冒相似，可能未被诊断出来。然而，婴儿和老年人有发展为重症病例的风险，这可能导致高发病率和死亡率，尤其是在存在潜在健康问题的情况下。尽管经过多年努力，但仍没有疫苗或特效治疗方法，RSV仍是全球婴儿住院的主要原因。在此，我们描述了感染两种广泛使用的小动物模型的方法：实验室小鼠和棉鼠。
