Pediatric Intensive Care Unit, Emma Children’s Hospital, Academic Medical Center, Amsterdam, The Netherlands.
Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L148-56. doi: 10.1152/ajplung.00065.2011. Epub 2011 May 13.
Infection with the human pneumovirus pathogen, respiratory syncytial virus (hRSV), causes a wide spectrum of respiratory disease, notably among infants and the elderly. Laboratory animal studies permit detailed experimental modeling of hRSV disease and are therefore indispensable in the search for novel therapies and preventative strategies. Present animal models include several target species for hRSV, including chimpanzees, cattle, sheep, cotton rats, and mice, as well as alternative animal pneumovirus models, such as bovine RSV and pneumonia virus of mice. These diverse animal models reproduce different features of hRSV disease, and their utilization should therefore be based on the scientific hypothesis under investigation. The purpose of this review is to summarize the strengths and limitations of each of these animal models. Our intent is to provide a resource for investigators and an impetus for future research.
人类呼吸道合胞病毒（hRSV）病原体感染可引起广泛的呼吸道疾病，尤其是在婴儿和老年人中。实验室动物研究允许对 hRSV 疾病进行详细的实验建模，因此在寻找新的治疗方法和预防策略方面是不可或缺的。目前的动物模型包括几种 hRSV 的目标物种，如黑猩猩、牛、羊、棉鼠和小鼠，以及替代动物呼吸道病毒模型，如牛呼吸道合胞病毒和鼠肺炎病毒。这些不同的动物模型再现了 hRSV 疾病的不同特征，因此其使用应基于正在研究的科学假设。本文旨在总结这些动物模型的优缺点。我们的目的是为研究人员提供资源，并推动未来的研究。
