Oral Nanoscience, School of Oral & Dental Sciences, University of Bristol, UK.
School of Health Sciences, Cardiff Metropolitan University, UK.
Nanomedicine (Lond). 2016 Aug;11(16):2049-57. doi: 10.2217/nnm-2016-0084. Epub 2016 Jul 28.
In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
MATERIALS & METHODS: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis.
CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.
本研究旨在探索六亚甲基二膦酸氯己定（CHX-HMP）作为一种持久的抗菌涂层，用于伤口护理材料。
将 CHX-HMP 用作伤口护理材料涂层，并就抗菌效果、毒性和伤口闭合与氯己定葡萄糖酸盐材料进行比较。
实验和商业材料均观察到第 1、3 和 7 天的抗菌效果。CHX-HMP 涂层材料对人胎盘细胞的毒性作用小于商业氯己定敷料。泊洛沙姆凝胶中的 CHX-HMP 不会延迟愈合，但可减少粪肠球菌对伤口的定植。
CHX-HMP 可成为一种有用的伤口护理材料成分，具有持续的抗菌效果、比氯己定葡萄糖酸盐材料更低的毒性，以及减少伤口定植而不影响闭合的效果。
