Gómez Victoria, Woodman George, Abu Dayyeh Barham K
Division of Gastroenterology, Mayo Clinic, Jacksonville, Florida, USA.
Midsouth Bariatrics, Memphis, Tennessee, USA.
Obesity (Silver Spring). 2016 Sep;24(9):1849-53. doi: 10.1002/oby.21555. Epub 2016 Jul 28.
The effects of intragastric balloon (IGB) therapy on gastric emptying (GE) and weight loss remain to be fully understood. The effects of IGB on GE were investigated in this study.
This was a single-center, randomized, controlled study in which subjects with obesity either underwent IGB placement or were matched controls. IGB was removed at 6 months. GE was measured at baseline and at weeks 0, 8, 16, 27, and 39. Percent total body weight loss (%TBWL) was measured at 6 and 12 months.
Twenty-nine subjects with obesity were enrolled; 15 were randomized to IGB placement and 14 to control. Two subjects had the IGB removed early. At baseline, 1- and 2-h gastric retention values were comparable between the groups but increased in the IGB group at weeks 8 and 16 (during IGB treatment) and then returned to baseline levels at 27 and 39 weeks. A greater increase in gastric retention from baseline to 8 weeks was associated with higher %TBWL.
GE in subjects with IGB is delayed but returns to normal after IGB removal. Greater changes in increased gastric retention were associated with greater %TBWL. Altering gastric motility is a significant mechanism of action by which the IGB results in weight loss.
胃内球囊（IGB）治疗对胃排空（GE）和体重减轻的影响仍有待充分了解。本研究调查了IGB对GE的影响。
这是一项单中心、随机对照研究，肥胖受试者要么接受IGB置入，要么作为匹配对照。IGB在6个月时取出。在基线、第0、8、16、27和39周测量GE。在6个月和12个月时测量总体重减轻百分比（%TBWL）。
纳入29名肥胖受试者；15名随机接受IGB置入，14名作为对照。2名受试者提前取出IGB。基线时，两组间1小时和2小时胃潴留值相当，但IGB组在第8周和16周（IGB治疗期间）升高，然后在第27周和39周恢复到基线水平。从基线到第8周胃潴留增加幅度越大，%TBWL越高。
接受IGB治疗的受试者胃排空延迟，但在IGB取出后恢复正常。胃潴留增加的更大变化与更高的%TBWL相关。改变胃动力是IGB导致体重减轻的一个重要作用机制。
