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创伤后过度晚期死亡的原因与匹配对照队列比较。

Causes of excessive late death after trauma compared with a matched control cohort.

机构信息

Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, Solna, Sweden.

Section of Anaesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

出版信息

Br J Surg. 2016 Sep;103(10):1282-9. doi: 10.1002/bjs.10197. Epub 2016 Jul 28.

Abstract

BACKGROUND

Studies on mortality following trauma have been restricted mainly to in-hospital or 30-day death. Mortality risk may be sustained several years after trauma, but the causes of late death have not been elucidated. The aim was to investigate mortality and analyse causes of late death after trauma.

METHODS

All injured patients from a regional trauma registry with long-term follow-up were matched in a 1 : 5 ratio with uninjured controls by age, sex and municipality. By linkage to national registries, long-term mortality, causes of death and co-morbidity status were identified. Excess mortality was examined by calculating the all-cause mortality rate ratio (MRR).

RESULTS

Among the trauma cohort of 7382 patients, 662 (9·0 per cent) died within 3 years after the index trauma; the 30-day mortality rate was 5·0 per cent. Compared with the control group (36 759 individuals), there was a sustained increase in mortality up to 3 years after trauma; the MRR was 2·88 (95 per cent c.i. 2·37 to 3·50) for days 31-365, 1·59 (1·24 to 2·04) for years 1-2 and 1·43 (1·06 to 1·92) for years 2-3. External causes, including new trauma, were far more common causes of late death in injured patients than in matched controls.

CONCLUSION

Postinjury mortality is increased for several years after trauma. Excess mortality is largely attributed to recurrent trauma and other external causes of death.

摘要

背景

关于创伤后死亡率的研究主要局限于院内或 30 天内的死亡。创伤后数年可能仍存在死亡风险,但晚期死亡的原因尚未阐明。本研究旨在调查创伤后死亡率,并分析晚期死亡的原因。

方法

通过对长期随访的区域创伤登记数据库中的所有受伤患者进行 1:5 年龄、性别和市匹配,与未受伤对照进行匹配。通过与国家登记处的链接,确定长期死亡率、死因和合并症状况。通过计算全因死亡率比(MRR)来评估超额死亡率。

结果

在 7382 例创伤患者队列中,有 662 例(9.0%)在指数创伤后 3 年内死亡;30 天死亡率为 5.0%。与对照组(36759 人)相比,创伤后 3 年内死亡率持续升高;MRR 分别为 31-365 天 2.88(95%可信区间 2.37 至 3.50)、1-2 年 1.59(1.24 至 2.04)和 2-3 年 1.43(1.06 至 1.92)。外部原因,包括新的创伤,是受伤患者晚期死亡的远较常见原因,比匹配对照组更常见。

结论

创伤后数年死亡率仍增加。超额死亡率主要归因于复发性创伤和其他外部死因。

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