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创伤后发病率,以病假衡量,数量可观,且受到与损伤无关的因素影响:一项回顾性匹配观察队列研究。

Post-trauma morbidity, measured as sick leave, is substantial and influenced by factors unrelated to injury: a retrospective matched observational cohort study.

机构信息

Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, SE-171 76, Stockholm, Sweden.

Section of Anaesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

出版信息

Scand J Trauma Resusc Emerg Med. 2017 Oct 13;25(1):100. doi: 10.1186/s13049-017-0444-3.

Abstract

BACKGROUND

Mortality as an endpoint has been the focus of trauma research whereas few studies investigate long-term outcomes in terms of morbidity. An adequate analysis of post-injury morbidity includes several dimensions, for this reason sick leave has been used as a proxy for morbidity in the current study. The aim of this retrospective matched observational cohort study was to investigate sick leave before and after trauma and factors associated with prolonged sick leave.

METHODS

Patients from a level one trauma centre 2005-2010 were matched in a 1:5 ratio with uninjured controls. By linkage to national registries, sick leave rates were compared. The association between potential risk factors and full-time sick leave at twelve months post injury, the primary end-point, was examined in trauma patients by logistic regression.

RESULTS

Four thousand seven hundred twelve patients and 25,013 controls aged 20-63 were included. Trauma patients had more sick leave both before and after trauma. Age, psychiatric disease, low level of education, serious injury, spinal injury, reduced consciousness at admission, discharge destination other than home, and hospital length of stay >7 days were all associated with the primary end-point. The strongest risk factor was sick leave before trauma; this was also noted in the most seriously injured patients.

DISCUSSION

In this retrospective matched observational cohort study we found a significant long-term morbidity, measured as sick leave, among trauma patients. Compared to controls the difference was maximal early after trauma and sustained throughout the follow up period. In the logistic regression, factors associated with the traumatic injury as well as host factors increased the probability of not returning to work. Full sick leavemonth twelve post injury was strongly associated with pre-injury sick leave but also with age, psychiatric comorbidity, level of education, injury severity, spinal injury, low GCS at admission, length of stay at hospital and discharge to other destination than home.

CONCLUSIONS

Trauma patients suffer from significant long-term morbidity. The sustained post-trauma morbidity is largely influenced by factors not related to injury per se. These insights enable identification of patients at risk for prolonged sick leave after trauma.

摘要

背景

作为终点的死亡率一直是创伤研究的焦点,而很少有研究从发病率的角度来探讨长期结果。对受伤后发病率进行充分分析包括多个方面,因此在本研究中,病假被用作发病率的替代指标。这项回顾性匹配观察性队列研究的目的是调查创伤前后的病假情况以及与病假延长相关的因素。

方法

2005 年至 2010 年,在一级创伤中心的患者与未受伤的对照组以 1:5 的比例进行匹配。通过与国家登记处的链接,比较了病假率。通过逻辑回归,检查了潜在危险因素与受伤后 12 个月时全时病假(主要终点)之间的关联。

结果

共纳入了 4712 名患者和 25013 名年龄在 20-63 岁的对照组。创伤患者在受伤前后的病假时间都更长。年龄、精神疾病、低教育水平、严重损伤、脊柱损伤、入院时意识降低、出院目的地非家庭、以及住院时间>7 天均与主要终点相关。最强的危险因素是受伤前的病假;在受伤最严重的患者中也观察到了这一点。

讨论

在这项回顾性匹配观察性队列研究中,我们发现创伤患者存在显著的长期发病率,表现为病假。与对照组相比,这种差异在创伤后早期最大,并持续整个随访期。在逻辑回归中,与创伤相关的因素以及宿主因素增加了无法恢复工作的概率。受伤后 12 个月的全病假与受伤前的病假密切相关,但也与年龄、精神合并症、教育程度、损伤严重程度、脊柱损伤、入院时 GCS 较低、住院时间以及出院到其他目的地有关。

结论

创伤患者患有明显的长期发病率。持续的创伤后发病率在很大程度上受到与损伤本身无关的因素的影响。这些发现使我们能够识别出创伤后病假延长的高风险患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb1a/5640905/1ed1642bbd76/13049_2017_444_Fig1_HTML.jpg

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