Haynes H R, Melegh Z, Vanjani S, Cieka M, Beavers S, Rooney N, Purdue B
Level 1 Neuroscience, Learning and Research Building, University of Bristol, Bristol, BS10 5NB, UK.
Department of Cellular Pathology, North Bristol NHS Trust, Bristol, UK.
Forensic Sci Med Pathol. 2016 Dec;12(4):486-490. doi: 10.1007/s12024-016-9800-2. Epub 2016 Jul 27.
A previously well 15-year-old female who was awaiting medical investigations for a proptosed right eye collapsed and died suddenly while walking. Postmortem examination revealed diffuse distortion and infiltration of multiple organs by a suspected neoplastic process. Histology confirmed the invasion of multiple organs by atypical cells and myocardial infiltration was the likely cause of death. An extensive panel of immunohistochemistry established the diagnosis of a histiocytic sarcoma. Sudden unexpected death due to a clinically undiagnosed neoplasia in childhood and adolescence is uncommon. This is the first report of a histiocytic sarcoma causing sudden unexpected death and highlights the importance of considering undiagnosed hematological malignancies when examining a case of sudden death at postmortem.
一名此前健康的15岁女性，因右眼突出正在等待医学检查，在行走时突然晕倒并死亡。尸检显示多个器官因疑似肿瘤过程而出现弥漫性变形和浸润。组织学证实多个器官被非典型细胞浸润，心肌浸润可能是死因。广泛的免疫组织化学检测确诊为组织细胞肉瘤。儿童和青少年因临床未诊断的肿瘤导致的意外猝死并不常见。这是首例关于组织细胞肉瘤导致意外猝死的报告，强调了尸检时检查猝死病例时考虑未诊断血液系统恶性肿瘤的重要性。
