Guo Min, Ding Guo-Bin, Yang Peng, Zhang Lichao, Wu Haili, Li Hanqing, Li Zhuoyu
College of Life Science and ‡Institute of Biotechnology, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University , Taiyuan 030006, China.
J Agric Food Chem. 2016 Aug 17;64(32):6277-85. doi: 10.1021/acs.jafc.6b01906. Epub 2016 Aug 3.
Nostoc commune Vauch., classified into cyanobacteria, has been always well appreciated as a healthy food and medicine worldwide owing to its rich nutrition and potent bioactivities. Nevertheless, the inhibitory effect of polysaccharides from N. commune Vauch. (NVPS) against cancer cell progression and metastasis is still being unraveled. The results in this study showed that NVPS remarkably suppressed cell migration through blocking the epithelial-mesenchymal transition program in NCI-H446 and NCI-H1688 human small cell lung cancer cells. The inhibitory effects were attributed to the suppression of integrin β1/FAK signaling through regulating cell-matrix adhesion. Furthermore, NVPS treatment could increase E-cadherin expression, but down-regulate N-cadherin, Vimentin, and MMP-9 expression, which resulted in the blockage of STAT3 nuclear translocation and JAK1 signaling. These findings suggest that NVPS may be a good candidate for development as a possible antitumor agent against small cell lung cancer.
普通念珠藻，分类为蓝细菌，因其丰富的营养和强大的生物活性，在全球范围内一直被视为健康食品和药物。然而，普通念珠藻多糖（NVPS）对癌细胞进展和转移的抑制作用仍在研究中。本研究结果表明，NVPS通过阻断NCI-H446和NCI-H1688人小细胞肺癌细胞中的上皮-间质转化程序，显著抑制细胞迁移。这种抑制作用归因于通过调节细胞-基质粘附来抑制整合素β1/FAK信号传导。此外，NVPS处理可增加E-钙粘蛋白的表达，但下调N-钙粘蛋白、波形蛋白和MMP-9的表达，从而导致STAT3核转位和JAK1信号传导的阻断。这些发现表明，NVPS可能是开发抗小细胞肺癌的潜在抗肿瘤药物的良好候选者。
