Guo Min, Ding Guo-Bin, Guo Songjia, Li Zhuoyu, Zhao Liangqi, Li Ke, Guo Xiangrong
Institute of Biotechnology, The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, People's Republic of China.
Food Funct. 2015 Sep;6(9):3035-44. doi: 10.1039/c5fo00471c.
Nostoc commune Vauch. has been traditionally used as a healthy food and medicine for centuries especially in China. It has been demonstrated that the polysaccharides isolated from Nostoc commune Vauch. exhibit strong antimicrobial and antioxidant activities. However, little is known about their anticancer activities and the underlying mechanisms of action. Herein, we report the isolation of a polysaccharide from Nostoc commune Vauch. (NVPS), and its physicochemical properties were analyzed. In an attempt to demonstrate the potential application of NVPS in tumor chemotherapy, the in vitro antitumor activity was determined. NVPS significantly suppressed the growth and proliferation of MCF-7 and DLD1 cells. The molecular mechanism underlying this in vitro antitumor efficacy was elucidated, and the results indicated that NVPS simultaneously triggered intrinsic, extrinsic and endoplasmic reticulum stress (ERS)-mediated apoptotic signaling pathways. Collectively, these findings demonstrate that NVPS could be used as a novel promising source of natural antitumor agents.
普通念珠藻（Nostoc commune Vauch.）几个世纪以来一直被用作保健食品和药物，尤其在中国。已证明从普通念珠藻中分离出的多糖具有很强的抗菌和抗氧化活性。然而，关于它们的抗癌活性及其潜在作用机制却知之甚少。在此，我们报道了从普通念珠藻中分离出一种多糖（NVPS），并对其理化性质进行了分析。为了证明NVPS在肿瘤化疗中的潜在应用，我们测定了其体外抗肿瘤活性。NVPS显著抑制了MCF-7和DLD1细胞的生长和增殖。阐明了这种体外抗肿瘤疗效的分子机制，结果表明NVPS同时触发了内在、外在和内质网应激（ERS）介导的凋亡信号通路。总的来说，这些发现表明NVPS可作为一种新型且有前景的天然抗肿瘤剂来源。
