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一名系统性红斑狼疮患者体内补体第九成分(C9)缺乏。

Deficiency of the 9th component of complement (C9) in a patient with systemic lupus erythematosus.

作者信息

Kawai T, Katoh K, Narita M, Tani K, Okubo T

机构信息

First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.

出版信息

J Rheumatol. 1989 Apr;16(4):542-3.

PMID:2746595
Abstract

We describe the first case of systemic lupus erythematosus (SLE) showing the 9th component of complement (C9) deficiency. In the serum of this patient, a low level of serum total hemolytic complement (CH50) and the absence of C9 was demonstrated. The patient's sister, with normal level of C9, was also found to have an autoimmune disorder.

摘要

我们描述了首例系统性红斑狼疮(SLE)患者出现补体第九成分(C9)缺乏的情况。在该患者血清中,检测到血清总溶血补体(CH50)水平较低且不存在C9。该患者的姐姐C9水平正常,但也被发现患有自身免疫性疾病。

相似文献

1
Deficiency of the 9th component of complement (C9) in a patient with systemic lupus erythematosus.一名系统性红斑狼疮患者体内补体第九成分(C9)缺乏。
J Rheumatol. 1989 Apr;16(4):542-3.
2
[A case of systemic lupus erythematosus in late component (C9) complement deficiency].[一例终末补体成分(C9)缺乏的系统性红斑狼疮病例]
Ryumachi. 1994 Jun;34(3):628-32.
3
Recurrent meningitis in a patient with congenital deficiency of the C9 component of complement. First case of C9 deficiency in Europe.一名患有补体C9成分先天性缺陷的患者反复发生脑膜炎。欧洲首例C9缺陷病例。
Arch Intern Med. 1990 Nov;150(11):2395-9.
4
Deficiency of the ninth component of complement in man.人类补体第九成分缺乏症。
J Clin Lab Immunol. 1979 Apr;2(1):85-7.
5
Radioimmunoassay of the attack complex of complement in serum from patients with systemic lupus erythematosus.系统性红斑狼疮患者血清中补体攻膜复合物的放射免疫测定
N Engl J Med. 1985 Jun 20;312(25):1594-9. doi: 10.1056/NEJM198506203122502.
6
Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity.C1q多态性分析表明其与系统性红斑狼疮、血清C1q及总补体活性水平以及疾病严重程度相关。
Ann Rheum Dis. 2009 May;68(5):715-20. doi: 10.1136/ard.2007.085688. Epub 2008 May 26.
7
Which complement assays and typings are necessary for the diagnosis of complement deficiency in patients with lupus erythematosus? A study of 25 patients.诊断红斑狼疮患者补体缺乏需要哪些补体检测和分型?对25例患者的研究。
Clin Immunol. 2006 Nov;121(2):198-202. doi: 10.1016/j.clim.2006.08.007. Epub 2006 Sep 20.
8
Complement component 9 deficiency is not a susceptibility factor for SLE.
Lupus. 2000;9(6):456-7. doi: 10.1191/096120300678828523.
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The role of C9 in complement-mediated killing of Neisseria.C9在补体介导的奈瑟菌杀伤中的作用。
J Immunol. 1981 Dec;127(6):2386-90.
10
Systemic lupus erythematosus in a patient with C4 deficiency.一名患有C4缺乏症患者的系统性红斑狼疮
J Rheumatol. 1981 Sep-Oct;8(5):741-6.

引用本文的文献

1
C9 deficiency in a patient with poststreptococcal glomerulonephritis.一名患有链球菌感染后肾小球肾炎患者的C9缺陷。
Pediatr Nephrol. 1995 Dec;9(6):746-8. doi: 10.1007/BF00868729.
2
Infectious diseases associated with complement deficiencies.与补体缺陷相关的传染病。
Clin Microbiol Rev. 1991 Jul;4(3):359-95. doi: 10.1128/CMR.4.3.359.
3
Systemic lupus erythematosus: RNA-protein autoantigens, models of disease heterogeneity, and theories of etiology.系统性红斑狼疮:RNA-蛋白质自身抗原、疾病异质性模型及病因学理论
J Clin Immunol. 1991 Nov;11(6):297-316. doi: 10.1007/BF00918796.