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人类补体第九成分缺乏症。

Deficiency of the ninth component of complement in man.

作者信息

Inai S, Kitamura H, Hiramatsu S, Nagaki K

机构信息

Department of Immunology, Center for Adult Diseases, Osaka, Japan.

出版信息

J Clin Lab Immunol. 1979 Apr;2(1):85-7.

PMID:95812
Abstract

The studies of serum from a case with C9 (the ninth component of complement) deficiency are described. A 29-year-old woman in good health was found to have low serum complement levels (CH50). C9 of her serum was undetectable by the hemolytic assay and by the immunochemical analysis but all other components were normal. It was demonstrated that low CH50 of her serum was due to the hemolysis of the sensitized sheep erythrocytes (EA) by the complement components from C1 to C8.

摘要

本文描述了对一名C9(补体第九成分)缺乏症患者血清的研究。一名29岁身体健康的女性被发现血清补体水平(CH50)较低。通过溶血试验和免疫化学分析,均未检测到其血清中的C9,但所有其他成分均正常。结果表明,其血清中CH50较低是由于补体成分C1至C8对致敏绵羊红细胞(EA)的溶血作用所致。

相似文献

1
Deficiency of the ninth component of complement in man.人类补体第九成分缺乏症。
J Clin Lab Immunol. 1979 Apr;2(1):85-7.
2
Inherited deficiency of the ninth component of complement in man.人类补体第九成分的遗传性缺陷。
J Immunol. 1980 Nov;125(5):2252-7.
3
The role of C9 in complement-mediated killing of Neisseria.C9在补体介导的奈瑟菌杀伤中的作用。
J Immunol. 1981 Dec;127(6):2386-90.
4
Deficiency of the 9th component of complement (C9) in a patient with systemic lupus erythematosus.一名系统性红斑狼疮患者体内补体第九成分(C9)缺乏。
J Rheumatol. 1989 Apr;16(4):542-3.
5
Recurrent meningitis in a patient with congenital deficiency of the C9 component of complement. First case of C9 deficiency in Europe.一名患有补体C9成分先天性缺陷的患者反复发生脑膜炎。欧洲首例C9缺陷病例。
Arch Intern Med. 1990 Nov;150(11):2395-9.
6
Hereditary deficiency of the fifth component of complement in man. I. Clinical, immunochemical, and family studies.人类补体第五成分的遗传性缺陷。I. 临床、免疫化学及家系研究。
J Clin Invest. 1976 Jun;57(6):1626-34. doi: 10.1172/JCI108433.
7
[The association between deficiency of terminal complement components and the occurrence of meningococcal meningitis].[终末补体成分缺乏与脑膜炎球菌性脑膜炎发生之间的关联]
Fukuoka Igaku Zasshi. 1992 May;83(5):201-8.
8
Further studies on C9 deficiency.关于C9缺陷的进一步研究。
J Clin Lab Immunol. 1981 Jul;6(1):7-11.
9
Inherited deficiency of the ninth component of complement associated with streptococcal infection.与链球菌感染相关的补体第九成分遗传性缺陷。
Acta Paediatr Jpn. 1992 Apr;34(2):169-72. doi: 10.1111/j.1442-200x.1992.tb00945.x.
10
Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9.CD59对同源补体的抑制作用是通过与C5b-8中的C8或C5b-9中的C9结合所赋予的物种选择性识别来介导的。
J Immunol. 1991 Apr 1;146(7):2345-51.

引用本文的文献

1
Genetic Association of the Porcine C9 Complement Component with Hemolytic Complement Activity.猪C9补体成分与溶血补体活性的遗传关联。
Asian-Australas J Anim Sci. 2015 Sep;28(9):1354-61. doi: 10.5713/ajas.14.0734.
2
SLE-like and sicca symptoms in late component (C9) complement deficiency.终末补体成分(C9)缺乏症中的系统性红斑狼疮样症状和干燥症状
Ann Rheum Dis. 1987 Feb;46(2):153-5. doi: 10.1136/ard.46.2.153.
3
C3-independent immune haemolysis: mechanism of membrane attack complex formation.不依赖补体C3的免疫性溶血:膜攻击复合物的形成机制
Immunology. 1986 Sep;59(1):147-51.
4
The activation of C5 in the fluid phase and in the absence of C3 through the classical pathway of the complement system.补体系统经典途径在液相且无C3时C5的激活。
Immunology. 1986 Jul;58(3):459-65.
5
Inhibition of immune haemolysis by a serum factor found in C3-deficient subjects.在C3缺陷患者血清中发现的一种血清因子对免疫性溶血的抑制作用。
Immunology. 1989 Feb;66(2):264-9.