Adriaans B, Garelick H
Department of Medical Microbiology, London School of Hygiene and Tropical Medicine.
J Med Microbiol. 1989 Jul;29(3):177-80. doi: 10.1099/00222615-29-3-177.
A new species of Fusobacterium, F. ulcerans, was isolated from 46 tropical ulcers. All the isolates had shown identical soluble cell protein patterns on polyacrylamide gel electrophoresis although there were two morphological types with slightly different biochemical properties. A representative strain of each of the two groups was selected for in- vitro cytotoxicity testing on a range of tissue-culture cell lines. Both strains of F. ulcerans induced a marked cytotoxic effect on Vero and Int-407 cells. This effect may contribute to the pathogenesis of tropical ulcers.
从46例热带溃疡患者中分离出一种新型梭杆菌——溃疮梭杆菌。尽管有两种形态类型且生化特性略有不同，但所有分离菌株在聚丙烯酰胺凝胶电泳上均显示出相同的可溶性细胞蛋白图谱。从两组中各选择一个代表性菌株，在一系列组织培养细胞系上进行体外细胞毒性测试。两种溃疮梭杆菌菌株均对Vero细胞和Int-407细胞产生显著的细胞毒性作用。这种作用可能有助于热带溃疡的发病机制。
