化疗对人体皮肤抗氧化状态的影响。

Influence of Chemotherapy on the Antioxidant Status of Human Skin.

作者信息

Lee Bich Na, Jung Sora, Darvin Maxim E, Eucker Jan, Kühnhardt Dagmar, Sehouli Jalid, Chekerov Radoslav, Patzelt Alexa, Fuss Harald, Yu Ruo-Xi, Lademann Jürgen

机构信息

Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité - University of Medicine Berlin, Berlin, Germany.

Department of Hematology and Oncology, Charité - University of Medicine Berlin, Berlin, Germany.

出版信息

Anticancer Res. 2016 Aug;36(8):4089-93.

PMID:27466518

Abstract

BACKGROUND

Palmoplantar erythrodysesthesia is a frequent dermal side-effect during chemotherapy. Previous investigations showed radical formation subsequent to doxorubicin infusion and preventative and therapeutic effects of an antioxidant-containing ointment.

PATIENTS AND METHODS

Using a non-invasive vivomeasuring system (Biozoom®; Biozoom Services GmbH, Kassel, Germany) changes in the antioxidant status (as measured by relative carotenoid concentration) of the skin prior to and after intravenous administration of paclitaxel, docetaxel and 5-fluorouracil were investigated in 42 patients with cancer.

RESULTS

A significant decrease of antioxidant concentration subsequent to intravenous administration was found for all investigated chemotherapeutic agents. The mean concentration of carotenoids decreased from 3.59±1.26 arbitrary units (a.u.) to 3.41±1.28 a.u. (p<0.001) after paclitaxel administration, from 6.33±2.43 to 5.63±2.29 a.u. after docetaxel (p=0.027) and from 4.26±1.81 to 3.98±1.53 a.u. (p=0.042) after 5-fluorouracil infusion.

CONCLUSION

Oxidative stress might play a significant role in the pathomechanism of palmoplantar erythrodysesthesia associated with paclitaxel, docetaxel and 5-fluorouracil. Therefore, an antioxidant-containing ointment might serve as preventative and therapeutic option.

摘要

背景

手足红斑性感觉异常是化疗期间常见的皮肤副作用。先前的研究表明，阿霉素输注后会产生自由基，以及含抗氧化剂软膏的预防和治疗作用。

患者和方法

使用非侵入性活体测量系统（Biozoom®；德国卡塞尔Biozoom Services GmbH公司），对42例癌症患者静脉注射紫杉醇、多西他赛和5-氟尿嘧啶前后皮肤的抗氧化状态变化（通过相对类胡萝卜素浓度测量）进行了研究。

结果

对于所有研究的化疗药物，静脉给药后抗氧化剂浓度均显著降低。紫杉醇给药后，类胡萝卜素的平均浓度从3.59±1.26任意单位（a.u.）降至3.41±1.28 a.u.（p<0.001），多西他赛后从6.33±2.43降至5.63±2.29 a.u.（p=0.027），5-氟尿嘧啶输注后从4.26±1.81降至3.98±1.53 a.u.（p=0.042）。