Karlikova Marie, Topolcan Ondrej, Narsanska Andrea, Kucera Radek, Treskova Inka, Treska Vladislav
Laboratory of Immunoanalysis, Faculty Hospital in Pilsen and Faculty of Medicine in Pilsen, Charles University in Prague, Prague, Czech Republic
Laboratory of Immunoanalysis, Faculty Hospital in Pilsen and Faculty of Medicine in Pilsen, Charles University in Prague, Prague, Czech Republic.
Anticancer Res. 2016 Aug;36(8):4209-14.
To evaluate the possibility of selected biomarkers for breast cancer diagnostics and/or treatment monitoring, lymph node (LN) status determination and clinical decision regarding axillary node dissection.
Two hundred and eleven patients with malignant breast cancer and 42 age-matched healthy controls were enrolled. Serum insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and plasma epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), osteoprotegerin (OPG) and osteopontin (OPN) were measured. We compared patients versus controls, patients with negative versus positive lymph node and patients with and without axillary lymph node dissection (ALND).
We found elevated IGF1 and VEGF levels in patients with lymph node metastases compared to controls (p=0.0179 and p=0.0091, respectively) and in patients with ALND (p=0.0337 and p=0.0438, respectively).
Circulating IGF1 and VEGF levels may predict the presence of lymph node metastases and help in the decision to avoid ALND in patients with early-stage breast cancer.
评估所选生物标志物用于乳腺癌诊断和/或治疗监测、确定淋巴结（LN）状态以及关于腋窝淋巴结清扫的临床决策的可能性。
招募了211例恶性乳腺癌患者和42例年龄匹配的健康对照者。检测血清胰岛素样生长因子1（IGF1）、胰岛素样生长因子结合蛋白3（IGFBP3）以及血浆表皮生长因子（EGF）、血管内皮生长因子（VEGF）、骨保护素（OPG）和骨桥蛋白（OPN）。我们比较了患者与对照者、淋巴结阴性与阳性的患者以及有和没有进行腋窝淋巴结清扫（ALND）的患者。
我们发现，与对照者相比，有淋巴结转移的患者（分别为p=0.0179和p=0.0091）以及进行了ALND的患者（分别为p=0.0337和p=0.0438）的IGF1和VEGF水平升高。
循环IGF1和VEGF水平可能预测淋巴结转移的存在，并有助于决定避免对早期乳腺癌患者进行ALND。
