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婴儿早期先天性梗阻性巨输尿管:诊断与治疗

Congenital obstructed megaureters in early infancy: diagnosis and treatment.

作者信息

Peters C A, Mandell J, Lebowitz R L, Colodny A H, Bauer S B, Hendren W H, Retik A B

机构信息

Division of Urology, Children's Hospital, Boston, Massachusetts.

出版信息

J Urol. 1989 Aug;142(2 Pt 2):641-5; discussion 667-8. doi: 10.1016/s0022-5347(17)38842-0.

Abstract

Fetal screening during maternal ultrasonography has changed the mode and age of presentation of congenital uropathies, particularly congenital obstructed megaureter. We studied 47 infants less than 8 months old with primary obstructed megaureter. Surgical correction in 42 patients with moderate to severe obstruction was performed at a mean age of 1.8 months in those detected prenatally and 3.8 months in those presenting after birth. All infants showed functional and structural urographic improvement with a mean followup of 2.3 years. Reflux was seen postoperatively in 8 patients, which subsided spontaneously in 3, continues to be followed in 2 and resulted in repeat reimplantation in 3. Five infants had mild obstruction, which was managed nonoperatively and 2 showed progressive obstruction, which required repair at ages 20 and 28 months. Repair of obstructed megaureters in early infancy improves renal drainage and offers the potential for preventing renal damage before the development of symptoms or infection. With proper attention to detail, excellent results may be achieved.

摘要

孕期超声检查中的胎儿筛查改变了先天性尿路疾病,尤其是先天性梗阻性巨输尿管的表现方式和发病年龄。我们研究了47例年龄小于8个月的原发性梗阻性巨输尿管婴儿。42例中重度梗阻患者,产前诊断出的平均手术矫正年龄为1.8个月,出生后诊断出的为3.8个月。所有婴儿经平均2.3年的随访,均显示出功能和结构上的尿路造影改善。术后8例出现反流,其中3例自行消退,2例继续随访,3例因反流导致再次行输尿管再植术。5例婴儿为轻度梗阻,采取非手术治疗,2例出现进行性梗阻,分别在20个月和28个月时进行修复。婴儿早期修复梗阻性巨输尿管可改善肾脏引流,并有可能在症状或感染出现之前预防肾脏损害。若能适当注重细节,可取得优异的效果。

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