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[原发性巨输尿管的诊断管理:排尿性膀胱尿道造影必不可少,闪烁扫描术是否有用?]

[Diagnostic management of primary megaureter : Voiding cystourethrography obligatory, scintigraphy useful?].

作者信息

Younsi N

机构信息

Zentrum für Kinder‑, Jugend- und rekonstruktive Urologie, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

出版信息

Urologe A. 2020 Mar;59(3):261-265. doi: 10.1007/s00120-020-01119-7.

DOI:10.1007/s00120-020-01119-7
PMID:32030434
Abstract

A primary, congenital megaureter means a dilatation of the ureter with a ureteric diameter ≥7 mm due to a structural or functional obstruction of the ureterovesical junction and represents the second most likely cause of neonatal hydronephrosis. Conservative management is the primary treatment option for many patients due to a high spontaneous remission rate of up to 85%. Concerning diagnostic management, meticulous and repeat postnatal evaluation by ultrasound is mandatory to identify patients who are at risk of renal deterioration. Routine voiding cystourethrography or contrast-enhanced voiding urosonography is currently recommended for all patients to detect vesicoureterorenal reflux and other concomitant pathologies. The relevance of the additional information provided by this examination must be critically questioned considering the lack of clinical consequences. Moreover, the question arises as to whether these examinations should be prolonged until clinical symptoms occur. Nevertheless, a subvesical obstruction should still be ruled out for male patients with a bilateral megaureter. The same critical discussion is necessary for the routine use of diuretic renography in patients with primary megaureter. In principal, this examination is used to determine the global as well as the split renal function and in addition is considered to offer an evaluation of the extent of obstruction. Similarly, the question arises of whether this examination should be mandatory for every child with a primary megaureter or whether the decision should be based on the extent of the upper urinary tract dilatation. The trend of diagnostic management should go towards individualized and risk-adapted diagnostic measures.

摘要

原发性先天性巨输尿管是指由于输尿管膀胱连接部的结构或功能障碍导致输尿管扩张,输尿管直径≥7毫米,是新生儿肾积水的第二大常见原因。由于高达85%的自发缓解率,保守治疗是许多患者的主要治疗选择。关于诊断管理,必须通过超声进行细致且重复的产后评估,以识别有肾功能恶化风险的患者。目前建议对所有患者进行常规排尿膀胱尿道造影或对比增强排尿超声检查,以检测膀胱输尿管反流和其他伴随病变。考虑到缺乏临床后果,必须对这项检查所提供的额外信息的相关性提出质疑。此外,还存在这些检查是否应延长至出现临床症状的问题。然而,对于双侧巨输尿管的男性患者,仍应排除膀胱下梗阻。对于原发性巨输尿管患者常规使用利尿肾图检查也有同样的关键讨论。原则上,这项检查用于确定整体以及分侧肾功能,此外还被认为可评估梗阻程度。同样,对于每一个原发性巨输尿管患儿是否都应强制进行这项检查,或者该决定是否应基于上尿路扩张程度,也存在疑问。诊断管理的趋势应朝着个体化和风险适应性诊断措施发展。

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1
[Diagnostic management of primary megaureter : Voiding cystourethrography obligatory, scintigraphy useful?].[原发性巨输尿管的诊断管理:排尿性膀胱尿道造影必不可少,闪烁扫描术是否有用?]
Urologe A. 2020 Mar;59(3):261-265. doi: 10.1007/s00120-020-01119-7.
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本文引用的文献

1
The Fate of Primary Nonrefluxing Megaureter: A Prospective Outcome Analysis of the Rate of Urinary Tract Infections, Surgical Indications and Time to Resolution.原发性非反流巨输尿管的结局:尿路感染发生率、手术指征和缓解时间的前瞻性结局分析。
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To V(CUG) or not to V(CUG) in infants with prenatal hydronephrosis?
产前肾积水婴儿是否采用V(CUG)检查?
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[Primary megaureter].[原发性巨输尿管]
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The fate of prenatally diagnosed primary nonrefluxing megaureter: do we have reliable predictors for spontaneous resolution?产前诊断的原发性无反流巨输尿管的转归:我们是否有预测自然缓解的可靠指标?
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Symptomatic and complicated adult and adolescent primary obstructive megaureter--indications for surgery: analysis, outcome, and follow-up.有症状和复杂的成人及青少年原发性梗阻性巨输尿管——手术指征:分析、结果及随访
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