Giacchi Giuseppe, Ortega-Paz Luis, Brugaletta Salvatore, Ishida Kohki, Sabaté Manel
Cardiology Department, Clinic Cardiovascular Institute, Hospital Clinic, August Pi and Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.
Med Devices (Auckl). 2016 Jul 11;9:185-98. doi: 10.2147/MDER.S90461. eCollection 2016.
Coronary bioresorbable vascular scaffolds are a new appealing therapeutic option in interventional cardiology. The most used and studied is currently the Absorb BVS™. Its backbone is made of poly-L-lactide and coated by a thin layer of poly-D,L-lactide, it releases everolimus and is fully degraded to H2O and CO2 in 2-3 years. Absorb BVS™ seems to offer several theoretical advantages over metallic stent, as it gives temporary mechanical support to vessel wall without permanently caging it. Therefore, long-term endothelial function and structure are not affected. A possible future surgical revascularization is not compromised. Natural vasomotion in response to external stimuli is also recovered. Several observational and randomized trials have been published about BVS clinical outcomes. The main aim of this review is to carry out a systematic analysis about Absorb BVS™ studies, evaluating also the technical improvements of the Absorb GT1 BVS™.
冠状动脉生物可吸收血管支架是介入心脏病学中一种新的有吸引力的治疗选择。目前使用最多且研究最多的是Absorb BVS™。它的主干由聚-L-丙交酯制成，并涂有一层薄薄的聚-D,L-丙交酯，释放依维莫司，在2至3年内完全降解为水和二氧化碳。与金属支架相比，Absorb BVS™似乎具有几个理论优势，因为它为血管壁提供临时机械支撑，而不会永久性地束缚它。因此，长期的内皮功能和结构不会受到影响。未来可能的外科血管重建也不会受到损害。对外部刺激的自然血管运动也会恢复。已经发表了几项关于生物可吸收血管支架临床结果的观察性和随机试验。本综述的主要目的是对Absorb BVS™研究进行系统分析，同时评估Absorb GT1 BVS™的技术改进。
