Li Yihang, Li Guang, Song Meifang, Li Xuelan, Zhan Xia, Lu Juan, Chen Xi
J Tradit Chin Med. 2016 Jun;36(3):377-81. doi: 10.1016/s0254-6272(16)30052-8.
To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata (A. obcordata) in Sprague Dawley rats.
The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were measured. After 14 days, the rats were sacrificed and their organs (liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology (e.g., hemoglobin and white blood cell counts) and clinical blood biochemistry (e.g., albumin and bilirubin) were also examined.
There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity (LD50) was estimated to be > 5000 mg/kg body weight.
Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long-term toxicity testing of A. obcordata is warranted.
研究倒心叶盾翅藤水提取物对斯普拉格-道利大鼠的急性毒性。
给大鼠口服5000毫克/千克体重的剂量，连续观察6小时，然后每天观察14天。对照大鼠给予蒸馏水。测定提取物对一般行为、体重以及食物和水摄入量的影响。14天后，处死大鼠并取出其器官（肝脏、心脏、脾脏、肺、肾脏、肾上腺、卵巢和睾丸）进行宏观检查。还检查了体重和器官重量，以及血液学指标（如血红蛋白和白细胞计数）和临床血液生化指标（如白蛋白和胆红素）。
未记录到死亡情况，用倒心叶盾翅藤处理的大鼠未表现出毒性迹象。与对照大鼠相比，用倒心叶盾翅藤处理的大鼠所有测量参数均未受影响。急性毒性（半数致死量）估计大于5000毫克/千克体重。
我们的结果证明了大鼠急性口服倒心叶盾翅藤水提取物的安全性，并表明有必要对倒心叶盾翅藤进行未来的亚急性和长期毒性试验。
