CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun 666303, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Molecules. 2020 Jan 25;25(3):529. doi: 10.3390/molecules25030529.
Four new diterpenoids, named aspidoptoids A-D (-), together with two known analogues (-) were isolated from vine. Aspidoptoids A-B (-) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B () possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their cytotoxic activities and inhibitory effects on the nitric oxide (NO) production.
从 藤本植物中分离得到四个新的二萜类化合物，命名为 aspidoptoids A-D（-），以及两个已知类似物（-）。Aspidoptoids A-B（-）是具有苯乙烯基的 20-降二萜类化合物的首例实例，其中 aspidoptoid B（）具有罕见的 3,10-氧桥。它们的结构和绝对构型通过广泛的光谱分析（IR、HRESIMS、1D 和 2D NMR）和电子圆二色性（ECD）计算确定。此外，还评估了所有分离物的细胞毒性活性和对一氧化氮（NO）产生的抑制作用。
