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Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder.成年小鼠大脑前脑中海马蛋白遗传破坏导致皮质突触改变和类似双相情感障碍的行为。
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本文引用的文献

1
A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia.ANK3 的一个次要异构体中的功能丧失变体可预防双相情感障碍和精神分裂症。
Biol Psychiatry. 2016 Aug 15;80(4):323-330. doi: 10.1016/j.biopsych.2015.09.021. Epub 2015 Nov 11.
2
Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.巨大锚蛋白G通过对抗GABAA受体的内吞作用来稳定树突状GABA能突触。
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1214-9. doi: 10.1073/pnas.1417989112. Epub 2014 Dec 31.
3
Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.巨型锚蛋白-G:脊椎动物快速且整合的神经元信号传导进化中的一项关键创新。
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):957-64. doi: 10.1073/pnas.1416544112. Epub 2014 Dec 31.
4
Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses.精神疾病风险因素ANK3/锚蛋白-G纳米结构域调节谷氨酸能突触的结构和功能。
Neuron. 2014 Oct 22;84(2):399-415. doi: 10.1016/j.neuron.2014.10.010.
5
Glial ankyrins facilitate paranodal axoglial junction assembly.神经胶质锚蛋白促进连接神经纤维的郎飞氏结处轴索-胶质连接的形成。
Nat Neurosci. 2014 Dec;17(12):1673-81. doi: 10.1038/nn.3858. Epub 2014 Nov 2.
6
Genome-wide association study reveals two new risk loci for bipolar disorder.全基因组关联研究揭示了双相情感障碍的两个新风险位点。
Nat Commun. 2014 Mar 11;5:3339. doi: 10.1038/ncomms4339.
7
Spectrin- and ankyrin-based membrane domains and the evolution of vertebrates.基于 spectrin 和 ankyrin 的膜结构域与脊椎动物的演化。
Curr Top Membr. 2013;72:1-37. doi: 10.1016/B978-0-12-417027-8.00001-5.
8
New findings in the genetics of major psychoses.重性精神病遗传学的新发现。
Dialogues Clin Neurosci. 2010;12(1):85-93. doi: 10.31887/DCNS.2010.12.1/mnoethen.
9
Abnormal neural oscillations and synchrony in schizophrenia.精神分裂症中的异常神经振荡和同步。
Nat Rev Neurosci. 2010 Feb;11(2):100-13. doi: 10.1038/nrn2774.
10
Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia.精神分裂症患者前额叶皮质中一类γ-氨基丁酸(GABA)神经元的基因表达缺陷。
J Neurosci. 2003 Jul 16;23(15):6315-26. doi: 10.1523/JNEUROSCI.23-15-06315.2003.

The Splice Is Right: ANK3 and the Control of Cortical Circuits.

作者信息

Nelson Andrew D, Jenkins Paul M

机构信息

Departments of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.

Departments of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan; Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan.

出版信息

Biol Psychiatry. 2016 Aug 15;80(4):263-265. doi: 10.1016/j.biopsych.2016.06.006.

DOI:10.1016/j.biopsych.2016.06.006
PMID:27468628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5103303/
Abstract
摘要