Liu Lu-Sha, Zhao Lan-Ying, Wang Shou-Hong, Jiang Jian-Ping
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;University of Chinese Academy of Sciences, Beijing 100049, China.
Dongwuxue Yanjiu. 2016 Jul 18;37(4):237-45. doi: 10.13918/j.issn.2095-8137.2016.4.237.
Model organisms have long been important in biology and medicine due to their specific characteristics. Amphibians, especially Xenopus, play key roles in answering fundamental questions on developmental biology, regeneration, genetics, and toxicology due to their large and abundant eggs, as well as their versatile embryos, which can be readily manipulated and developed in vivo. Furthermore, amphibians have also proven to be of considerable benefit in human disease research due to their conserved cellular developmental and genomic organization. This review gives a brief introduction on the progress and limitations of these animal models in biology and human disease research, and discusses the potential and challenge of Microhyla fissipes as a new model organism.
由于其特定的特征，模式生物长期以来在生物学和医学中都很重要。两栖动物，特别是非洲爪蟾，因其大量且丰富的卵以及多功能的胚胎（可以在体内轻松操作和发育），在回答发育生物学、再生、遗传学和毒理学等基本问题方面发挥着关键作用。此外，由于两栖动物保守的细胞发育和基因组组织，它们在人类疾病研究中也已证明具有相当大的益处。本综述简要介绍了这些动物模型在生物学和人类疾病研究中的进展与局限性，并讨论了作为一种新的模式生物的姬蛙的潜力和挑战。
