Farley Kathleen A, Reilly Usa, Anderson Dennis P, Boscoe Brian P, Bundesmann Mark W, Foley David A, Lall Manjinder S, Li Chao, Reese Matthew R, Yan Jiangli
Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
Magn Reson Chem. 2017 Apr;55(4):348-354. doi: 10.1002/mrc.4494. Epub 2016 Aug 11.
In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and other off-line spectroscopy tools to monitor the progress of a flow chemistry reaction. The on-line and off-line tools were selected to facilitate the stereoselective kinetic resolution of a key racemic monomer, which lacked a chromophore, making conventional reaction monitoring difficult. Copyright © 2016 John Wiley & Sons, Ltd.
