Gomez M Victoria, de la Hoz Antonio
Área Química Orgánica, Facultad de Químicas, Universidad de Castilla-La Mancha, Avda. Camilo José Cela nº 10, E-13071 Ciudad Real, Spain and Instituto Regional de Investigación Científica Aplicada (IRICA), Avda. Camilo José Cela s/n, E-13071 Ciudad Real, Spain.
Beilstein J Org Chem. 2017 Feb 14;13:285-300. doi: 10.3762/bjoc.13.31. eCollection 2017.
Recent advances in the use of flow chemistry with in-line and on-line analysis by NMR are presented. The use of macro- and microreactors, coupled with standard and custom made NMR probes involving microcoils, incorporated into high resolution and benchtop NMR instruments is reviewed. Some recent selected applications have been collected, including synthetic applications, the determination of the kinetic and thermodynamic parameters and reaction optimization, even in single experiments and on the μL scale. Finally, software that allows automatic reaction monitoring and optimization is discussed.
介绍了流动化学与核磁共振在线和联机分析联用的最新进展。综述了宏反应器和微反应器的使用，以及与包含微线圈的标准和定制核磁共振探头相结合，并集成到高分辨率和台式核磁共振仪器中的情况。收集了一些近期的特定应用，包括合成应用、动力学和热力学参数的测定以及反应优化，甚至在单实验和微升规模上也是如此。最后，讨论了允许自动反应监测和优化的软件。
