人牙髓干细胞中p75神经营养因子受体表达的特征分析
Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells.
作者信息
Pan Wenru, Kremer Karlea L, Kaidonis Xenia, Ludlow Victoria E, Rogers Mary-Louise, Xie Jianling, Proud Christopher G, Koblar Simon A
机构信息
School of Medical Science, Australia; South Australian Health & Medical Research Institute, South Australia, Australia.
School of Medicine, Australia; South Australian Health & Medical Research Institute, South Australia, Australia.
出版信息
Int J Dev Neurosci. 2016 Oct;53:90-98. doi: 10.1016/j.ijdevneu.2016.07.007. Epub 2016 Jul 26.
Human adult dental pulp stem cells (DPSC) are a heterogeneous stem cell population, which are able to differentiate down neural, chondrocyte, osteocyte and adipocyte lineages. We studied the expression pattern of p75 neurotrophin receptors (p75NTR), a marker of neural stem cells, within human DPSC populations from eight donors. p75NTR are expressed at low levels (<10%) in DPSC. Importantly, p75(+) DPSC represent higher expression levels of SOX1 (neural precursor cell marker), SOX2 (cell pluripotency marker) and nestin (neural stem cell marker) in comparison to p75(-) DPSC. Our results suggest that p75(+) hDPSC may denote a subpopulation with greater neurogenic potential.
人类成人牙髓干细胞（DPSC）是一种异质性干细胞群体，能够分化为神经细胞、软骨细胞、骨细胞和脂肪细胞谱系。我们研究了神经干细胞标志物p75神经营养因子受体（p75NTR）在来自八位供体的人类DPSC群体中的表达模式。p75NTR在DPSC中的表达水平较低（<10%）。重要的是，与p75（-）DPSC相比，p75（+）DPSC表现出更高水平的SOX1（神经前体细胞标志物）、SOX2（细胞多能性标志物）和巢蛋白（神经干细胞标志物）表达。我们的结果表明，p75（+）hDPSC可能代表具有更大神经发生潜能的亚群。
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