在比较性 EAE 研究中，精细化的临床评分并不能提高观察到统计学显著差异的机会。
Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences.
机构信息
Theodor Kocher Institute, University of Bern, Bern, Switzerland.
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
出版信息
Eur J Immunol. 2016 Oct;46(10):2481-2483. doi: 10.1002/eji.201546272. Epub 2016 Aug 31.
PMID:27469626
Abstract
Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis. Surprisingly, refined EAE scoring failed to improve statistical outcome comparing the overall disease courses between two groups of mice.
摘要
考虑到动物实验的 3R 原则，我们想知道是否可以通过对实验性自身免疫性脑脊髓炎（EAE）在小鼠中的评分进行细化，来改进临床 EAE 的记录，从而进行更强大的统计分析。令人惊讶的是，与两组小鼠的整体疾病过程相比，细化的 EAE 评分并没有改善统计结果。
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