Mitoh Y
Nihon Hifuka Gakkai Zasshi. 1989 Jan;99(1):9-14.
Twenty patients with xeroderma pigmentosum group A (XP-A) and 30 healthy controls were studied to determine the energy requirements for UV-erythema with monochromatic light between 255 and 340 nm. As test sites, unexposed skin on the upper back was selected for irradiation using a prism monochromator and a 1 kW xenon arc source. The minimal erythema doses (MEDs) were determined at each erythemal response peak, at 24 hours post irradiation in normal controls and at 72 hours in XP-A patients, respectively. Compared with normal subjects, XP-A patients had extremely low MEDs at all wavelengths tested. The erythema action spectrum showed 2 peaks at 265 and 290 nm in XP-A patients and the greatest effectiveness at 290 nm. These results indicate that XP-A patients should be protected strongly against not only UVB but also UVA, because the photo-hypersensitivity in XP-A patients has been extended from the UVB to UVA region.
对20名A型着色性干皮病（XP - A）患者和30名健康对照者进行了研究，以确定255至340纳米单色光引起紫外线红斑所需的能量。作为测试部位，选择上背部未暴露的皮肤，使用棱镜单色仪和1千瓦氙弧光源进行照射。分别在每个红斑反应峰值处、正常对照者照射后24小时以及XP - A患者照射后72小时测定最小红斑剂量（MED）。与正常受试者相比，XP - A患者在所有测试波长下的MED都极低。红斑作用光谱显示，XP - A患者在265和290纳米处有两个峰值，在290纳米处效果最佳。这些结果表明，XP - A患者不仅应受到强烈的紫外线B防护，还应受到紫外线A防护，因为XP - A患者的光超敏反应已从紫外线B区域扩展到了紫外线A区域。
