Remitz A
Department of Dermatology, Helsinki University Central Hospital, Finland.
Acta Derm Venereol. 1989;69(4):351-4.
Previous studies have shown that when butantrone and dithranol were used in equimolar gradually increasing concentrations in short-contact therapy for psoriasis the efficacy of butantrone was somewhat lower compared to dithranol. To see whether the efficacy of butantrone in short-contact therapy could be increased by starting with a single high-concentration directly, 20 psoriatic patients were treated with dithranol (0.1,-0.5,-1.0,-2.0%) and butantrone (3.9%) short-contact therapy as a right-left comparison. With these treatment modalities the antipsoriatic effects of dithranol and butantrone were similar. Although the efficacy of 3.9% butantrone was better than the previously used butantrone therapy with gradually increasing doses, there was a parallel increase in side-effects. In general, the side-effects (erythema and staining) remained weaker on the butantrone-treated side than on the dithranol-treated side. No systemic adverse-effects were observed in any of the treated patients.
先前的研究表明，在银屑病短程接触疗法中，当使用等摩尔浓度且逐渐递增的丁酮蒽醌和地蒽酚时，丁酮蒽醌的疗效与地蒽酚相比略低。为了探究直接从单一高浓度开始使用丁酮蒽醌是否能提高其在短程接触疗法中的疗效，20例银屑病患者接受了地蒽酚（0.1%、0.5%、1.0%、2.0%）和丁酮蒽醌（3.9%）短程接触疗法，左右两侧进行对照。采用这些治疗方式时，地蒽酚和丁酮蒽醌的抗银屑病效果相似。虽然3.9%丁酮蒽醌的疗效优于先前使用的剂量逐渐递增的丁酮蒽醌疗法，但其副作用也相应增加。总体而言，丁酮蒽醌治疗侧的副作用（红斑和染色）比地蒽酚治疗侧更轻。所有接受治疗的患者均未观察到全身不良反应。
