Kamide R
Department of Dermatology, Jikei University School of Medicine.
Nihon Rinsho. 1997 Sep;55(9):2259-61.
As post-transfusion graft-vs-host disease (GVHD) has poor prognosis, early diagnosis by skin biopsy is essential. The histopathology of the skin lesion includes a lymphocytic infiltration to the dermo-epidermal junction associated with vacuolization of the basal layer. Dyskeratotic or necrotic epidermal cells are scattered through the epidermis. Some of these necrotic cells are surrounded by a few lymphocytes (satellite cell necrosis). These histopathological findings are referred to as a lichenoid tissue reaction, but is not specific to GVHD, and can be seen in some types of drug eruption (toxic epidermal necrolysis type and erythema multiforme type). Final diagnosis will be confirmed by the clinical symptoms, such as liver dysfunction, diarrhea and pancytopenia.
由于输血后移植物抗宿主病（GVHD）预后较差，通过皮肤活检进行早期诊断至关重要。皮肤病变的组织病理学表现包括淋巴细胞浸润至真皮表皮交界处，并伴有基底层空泡化。角化不良或坏死的表皮细胞散在分布于整个表皮。其中一些坏死细胞被少数淋巴细胞包围（卫星细胞坏死）。这些组织病理学表现被称为苔藓样组织反应，但并非GVHD所特有，在某些类型的药疹（中毒性表皮坏死松解型和多形红斑型）中也可见到。最终诊断将通过肝功能障碍、腹泻和全血细胞减少等临床症状得以证实。
