Chen Chun-Yu, Tsai Yung-Fong, Chang Wen-Yi, Yang Shun-Chin, Hwang Tsong-Long
Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Mar Drugs. 2016 Jul 26;14(8):141. doi: 10.3390/md14080141.
Neutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases. Reactive oxygen species (ROS) and microbicidal compounds released from neutrophils that are recruited to the site of inflammation contribute to the pathogenesis of multiple inflammation-associated diseases such as chronic obstructive pulmonary disease, atherosclerosis, and hepatitis. Marine organisms are a valuable source of bioactive compounds with potential for industrial and pharmaceutical application. Marine natural products that inhibit neutrophil activation could be used as drugs for the treatment of inflammatory diseases. Numerous studies investigating marine natural products have reported novel anti-inflammatory agents. Nevertheless, the detailed mechanisms underlying their actions, which could facilitate our understanding of the molecular events occurring in neutrophils, have not been reported in most of the associated research studies. Therefore, in this review, we will present marine products that inhibit neutrophil-associated inflammation. Furthermore, we will be limiting the detailed discussion to agents with well-investigated molecular targets.
中性粒细胞在急性炎症反应中发挥重要作用已得到广泛认可，最近的证据表明它们在调节慢性炎症和自身免疫性疾病方面也发挥作用。招募到炎症部位的中性粒细胞释放的活性氧（ROS）和杀菌化合物会导致多种炎症相关疾病的发病机制，如慢性阻塞性肺疾病、动脉粥样硬化和肝炎。海洋生物是具有工业和制药应用潜力的生物活性化合物的宝贵来源。抑制中性粒细胞活化的海洋天然产物可作为治疗炎症性疾病的药物。许多研究海洋天然产物的报告都报道了新型抗炎剂。然而，在大多数相关研究中，尚未报道其作用的详细机制，而这些机制有助于我们理解中性粒细胞中发生的分子事件。因此，在本综述中，我们将介绍抑制中性粒细胞相关炎症的海洋产物。此外，我们将详细讨论限于具有充分研究分子靶点的药物。
