补体成分C1q与半抗原致敏脂质囊泡的特异性抗体依赖性结合。
Specific antibody-dependent binding of complement component C1q to hapten-sensitized lipid vesicles.
作者信息
Parce J W, Henry N, McConnell H M
出版信息
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1515-8. doi: 10.1073/pnas.75.3.1515.
Abstract
The binding of a component of human complement (C1q) to membrane-bound specific anti-nitroxide antibodies was studied as a function of the physical properties (fluid vs. solid) of vesicle lipids. The antibodies were bound to spin-label lipid haptens in the vesicle membrane. The binding of C1q to the sensitized vesicles shows a maximum as a function of specific IgG concentration. The binding of antibodies and of C1q to the vesicle membrane does not depend strongly on the physical state of the membrane lipids. even at low hapten (0.05 mol%) concentrations. These results are of significance for the understanding of the previously reported effect of lipid physical states on complement depletion.
摘要
研究了人类补体成分（C1q）与膜结合特异性抗氮氧化物抗体的结合情况，作为囊泡脂质物理性质（液态与固态）的函数。抗体与囊泡膜中的自旋标记脂质半抗原结合。C1q与致敏囊泡的结合随特异性IgG浓度的变化呈现最大值。抗体和C1q与囊泡膜的结合并不强烈依赖于膜脂质的物理状态，即使在低半抗原（0.05 mol%）浓度下也是如此。这些结果对于理解先前报道的脂质物理状态对补体消耗的影响具有重要意义。
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