Boon T, Van Pel A
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1519-23. doi: 10.1073/pnas.75.3.1519.
We reported previously that, by mutagenesis of a malignant teratocarcinoma cell line, it is possible to obtain a number of variant clones that are incapable of forming progressive tumors. Each of these "tum-" variants is rejected in syngeneic mice and stimulates the production of immune memory cells (self-protection). We show here that four different tum- clones confer an immune protection against each other although this cross-protection is invariably weaker than the self-protection. Moreover, mice immunized with living tum- cells are partially protected against the original malignant teratocarcinoma cells, even though the latter cells are incapable of conferring any immune protection when injected after being killed by irradiation. These results indicate that each tum- variant carries at least one specific transplantation antigen that is absent from the original tumor cell line and from most other tum- variants. Other tumor-specific transplantation antigens are probably present on all the tum- variants and also on the malignant teratocarcinoma cell line.
我们之前报道过，通过对恶性畸胎瘤细胞系进行诱变，有可能获得一些无法形成进展性肿瘤的变异克隆。这些“tum-”变异体中的每一个在同基因小鼠中都会被排斥，并刺激免疫记忆细胞的产生（自我保护）。我们在此表明，四个不同的tum-克隆相互之间能提供免疫保护，尽管这种交叉保护总是比自我保护弱。此外，用活的tum-细胞免疫的小鼠对原始恶性畸胎瘤细胞有部分保护作用，即使后者细胞在经辐射杀死后注射时无法提供任何免疫保护。这些结果表明，每个tum-变异体至少携带一种原始肿瘤细胞系和大多数其他tum-变异体所没有的特异性移植抗原。其他肿瘤特异性移植抗原可能存在于所有的tum-变异体以及恶性畸胎瘤细胞系上。
